Bordeaux, hub of the famed wine-growing region, is a port city on the Garonne River in southwestern France. It’s known for its Gothic Cathédrale Saint-André, 18th- to 19th-century mansions and notable art museums such as the Musée des Beaux-Arts de Bordeaux. Public gardens line the curving river quays. The grand Place de la Bourse, centered on the Three Graces fountain, overlooks the Miroir d’Eau reflecting pool.

Bordeaux, hub of the famed wine-growing region, is a port city on the Garonne River in southwestern France. It’s known for its Gothic Cathédrale Saint-André, 18th- to 19th-century mansions and notable art museums such as the Musée des Beaux-Arts de Bordeaux. Public gardens line the curving river quays. The grand Place de la Bourse, centered on the Three Graces fountain, overlooks the Miroir d’Eau reflecting pool.

Bordeaux, hub of the famed wine-growing region, is a port city on the Garonne River in southwestern France. It’s known for its Gothic Cathédrale Saint-André, 18th- to 19th-century mansions and notable art museums such as the Musée des Beaux-Arts de Bordeaux. Public gardens line the curving river quays. The grand Place de la Bourse, centered on the Three Graces fountain, overlooks the Miroir d’Eau reflecting pool.

Bilbao, an industrial port city in northern Spain, is surrounded by green mountains. It’s the de facto capital of Basque Country, with a skyscraper-filled downtown. It’s famed for the Frank Gehry–designed Guggenheim Museum Bilbao, which sparked revitalization when it opened in 1997. The museum houses prominent modern and contemporary works, but it’s the curvy, titanium-clad building that receives the most attention.

Gijón is a large coastal city in northern Spain. It’s known for its maritime heritage and the old fishermen’s quarter of Cimadevilla. Santa Catalina hill has a clifftop park and sculpture. The 18th-century Revillagigedo Palace houses an international arts center. It adjoins the Collegiate Church of San Juan Bautista, now a concert hall. Nearby is the 16th-century Clock Tower, with a museum about the city.

Vigo is a city on Spain’s northwest coast. The mouth of the nearby Vigo Estuary is sheltered by the Cíes Islands, which form part of the Atlantic Islands National Park. The Cíes are known for their rich birdlife and crescent-shaped Rodas Beach. The city’s old quarter is home to the neoclassical Church of Santa María. The Castro de Vigo archaeological site has reconstructed ancient dwellings.

One of Europe's smallest capital cities, Lisbon is for many, one of it most beguiling – an easily accessible mix of new and old worlds. Elegant outdoor cafés line Lisbon's mosaic cobblestone sidewalks along grand 18th-century boulevards. Turn-of-the-century funiculars dot its steep hills. Two-thirds of the city was leveled in a 1755 earthquake, but in its churches, peeling buildings, tiny alleyways, hidden squares, you can still feel the glorious past.