Venice, the capital of northern Italy’s Veneto region, is built on more than 100 small islands in a lagoon in the Adriatic Sea. It has no roads, just canals – including the Grand Canal thoroughfare – lined with Renaissance and Gothic palaces. The central square, Piazza San Marco, contains St. Mark’s Basilica, which is tiled with Byzantine mosaics, and the Campanile bell tower offering views of the city’s red roofs.

Venice, the capital of northern Italy’s Veneto region, is built on more than 100 small islands in a lagoon in the Adriatic Sea. It has no roads, just canals – including the Grand Canal thoroughfare – lined with Renaissance and Gothic palaces. The central square, Piazza San Marco, contains St. Mark’s Basilica, which is tiled with Byzantine mosaics, and the Campanile bell tower offering views of the city’s red roofs.

Šibenik is a city on the Adriatic coast of Croatia. It’s known as a gateway to the Kornati Islands. The 15th-century stone Cathedral of St. James is decorated with 71 sculpted faces. Nearby, the Šibenik City Museum, in the 14th-century Prince’s Palace, has exhibits ranging from prehistory to the present. The white stone St. Michael’s Fortress has an open-air theater, with views of Šibenik Bay and neighboring islands.

Bari is a port city on the Adriatic Sea, and the capital of southern Italy’s Puglia region. Its mazelike old town, Barivecchia, occupies a headland between 2 harbors. Surrounded by narrow streets, the 11th-century Basilica di San Nicola, a key pilgrimage site, holds some of St. Nicholas’ remains. To the south, the Murat quarter has stately 19th-century architecture, a promenade and pedestrianized shopping areas.

Crotone is a port city in Calabria, southern Italy. The monumental Castello di Carlo V is a 9th-century fortress that was modified in the 1500s. The National Archaeological Museum houses items, including a gold tiara, unearthed at the ancient Temple of Hera Lacinia in the nearby Capo Colonna Archaeological Park. Farther south is the Capo Rizzuto Marine Protected Area, with seagrass forests, barracudas and starfish

Sicily, the largest Mediterranean island, is just off the "toe" of Italy's "boot." Its rich history is reflected in sites like the Valley of the Temples, the well-preserved ruins of 7 monumental, Doric-style Greek temples, and in the Byzantine mosaics at the Cappella Palatina, a former royal chapel in capital city Palermo. On Sicily’s eastern edge is Mount Etna, one of Europe’s highest active volcanoes.

Naples, a city in southern Italy, sits on the Bay of Naples. Nearby is Mount Vesuvius, the still-active volcano that destroyed nearby Roman town Pompeii. Dating to the 2nd millennium B.C., Naples has centuries of important art and architecture. The city's cathedral, the Duomo di San Gennaro, is filled with frescoes. Other major landmarks include the lavish Royal Palace and Castel Nuovo, a 13th-century castle

Rome is the capital city and a special comune of Italy, as well as the capital of the Lazio region. The city has been a major human settlement for almost three millennia. With 2,860,009 residents in 1,285 km², it is also the country's most populated comune.