Valparaíso is a port city on Chile’s coast. It's known for its steep funiculars and colorful, clifftop homes. La Sebastiana, the quirky former residence of Chilean poet Pablo Neruda, is now a museum with far-reaching Pacific views. During the 19th century, an influx of European immigrants left their mark on the city’s architecture and cultural institutions, many of which congregate around downtown’s Plaza Sotomayor.

The Castro District, in Eureka Valley, is synonymous with gay culture. Revelers often spill onto the sidewalks at numerous bars, like Twin Peaks Tavern, whose floor-to-ceiling windows were revolutionary when it opened in 1972. The lavish Castro Theatre and the GLBT Historic Museum are also found here, as are homey restaurants and adult shops. On Market Street, 19th-century F-line streetcars head to Fisherman’s Wharf.

Patagonia is a region encompassing the vast southernmost tip of South America, shared by Argentina and Chile, with the Andes Mountains as its dividing line. The Argentine side features arid steppes, grasslands and deserts, while the Chilean has glacial fjords and temperate rainforest. Argentina’s famed RN-40 highway passes the pinnacles of Monte Fitz Roy and Perito Moreno Glacier in Los Glaciares National Park.

Tortel is a Chilean commune located at the outflow of the Baker River and Pascua River to the Pacific Ocean. It lies between the Northern and Southern Patagonian Ice Field in the Capitán Prat Province in the Aysén Region. The commune is administered by the municipality in Caleta Tortel, the principal settlement

The southern coast of Chile presents a large number of fjords and fjord-like channels from the latitudes of Cape Horn to Reloncaví Estuary. Some fjords and channels are important navigable channels providing access to ports like Punta Arenas, Puerto Chacabuco and Puerto Natales.

The southern coast of Chile presents a large number of fjords and fjord-like channels from the latitudes of Cape Horn to Reloncaví Estuary. Some fjords and channels are important navigable channels providing access to ports like Punta Arenas, Puerto Chacabuco and Puerto Natales.

Puerto Natales is a port city on the Señoret Channel in Chile’s southern Patagonia. It’s the gateway to Torres del Paine National Park to the northwest, and the port for boats touring the Patagonian fjords. The Municipal Historical Museum in the city center exhibits artifacts from the region’s indigenous population. To the north is the vast Mylodon Cave, once inhabited by prehistoric, slothlike mylodons.

The southern coast of Chile presents a large number of fjords and fjord-like channels from the latitudes of Cape Horn to Reloncaví Estuary. Some fjords and channels are important navigable channels providing access to ports like Punta Arenas, Puerto Chacabuco and Puerto Natales.

The southern coast of Chile presents a large number of fjords and fjord-like channels from the latitudes of Cape Horn to Reloncaví Estuary. Some fjords and channels are important navigable channels providing access to ports like Punta Arenas, Puerto Chacabuco and Puerto Natales.

Puerto Williams is a town on Navarino Island in the Beagle Channel in Chile’s far south. Part of the Tierra del Fuego archipelago, it’s known as a starting point for trips around Cape Horn. It’s also a gateway to trails around the jagged peaks of the nearby Dientes de Navarino. In town, the Martin Gusinde Anthropological Museum traces the history of the region’s former inhabitants, the indigenous Yaghan people.

Cape Horn is a rocky headland on Hornos Island, in southern Chile's Tierra del Fuego archipelago. It's surrounded by wild seas off the southern tip of South America where the Pacific and Atlantic oceans meet. The albatross-shaped Cape Horn Monument commemorates the lives of thousands of seafarers who perished attempting to sail around the cape. A secluded lighthouse and the tiny Stella-Maris Chapel are nearby.

Ushuaia is a resort town in Argentina. It's located on the Tierra del Fuego archipelago, the southernmost tip of South America, nicknamed the “End of the World.” The windswept town, perched on a steep hill, is surrounded by the Martial Mountains and the Beagle Channel. It's the gateway to Antarctica cruises and tours to nearby Isla Yécapasela, known as “Penguin Island” for its penguin colonies.

Buenos Aires is Argentina’s big, cosmopolitan capital city. Its center is the Plaza de Mayo, lined with stately 19th-century buildings including Casa Rosada, the iconic, balconied presidential palace. Other major attractions include Teatro Colón, a grand 1908 opera house with nearly 2,500 seats, and the modern MALBA museum, displaying Latin American art.