Basel is a city on the Rhine River in northwest Switzerland, close to the country’s borders with France and Germany. Its medieval old town centers around Marktplatz, dominated by the 16th-century, red-sandstone Town Hall. Its 12th-century Gothic cathedral has city views, and contains the tomb of the 16th-century Dutch scholar, Erasmus. The city’s university houses some of Erasmus’ works.

Breisach is a town with approximately 16,500 inhabitants, situated along the Rhine in the Rhine Valley, in the district Breisgau-Hochschwarzwald, Baden-Württemberg, Germany, about halfway between Freiburg and Colmar — 20 kilometres away from each — and about 60 kilometres north of Basel near the Kaiserstuhl.

Strasbourg is the capital city of the Grand Est region, formerly Alsace, in northeastern France. It's also the formal seat of the European Parliament and sits near the German border, with culture and architecture blending German and French influences. Its Gothic Cathédrale Notre-Dame features daily shows from its astronomical clock and sweeping views of the Rhine River from partway up its 142m spire.

Rüdesheim am Rhein is a town in the Rhine Valley, Germany. It’s known for winemaking, especially of Riesling wines. In the center, Drosselgasse is a lane lined with shops, taverns and restaurants. Nearby, Siegfried’s Mechanical Music Cabinet is a museum of automated musical instruments. Medieval Brömserburg Castle is home to the Rheingau Wine Museum, exhibiting wine paraphernalia from ancient times to the present.

Boppard, formerly also spelled Boppart, is a town and municipality in the Rhein-Hunsrück-Kreis in Rhineland-Palatinate, Germany, lying in the Rhine Gorge, a UNESCO World Heritage Site. The town is also a state-recognized tourism resort and is a winegrowing centre.

Frankfurt, a central German city on the river Main, is a major financial hub that's home to the European Central Bank. It's the birthplace of famed writer Johann Wolfgang von Goethe, whose former home is now the Goethe House Museum. Like much of the city, it was damaged during World War II and later rebuilt.

Würzburg is a city in Germany's Bavaria region. It's known for lavish baroque and rococo architecture, particularly the 18th-century Residenz palace, with ornate rooms, a huge fresco by Venetian artist Tiepolo and an elaborate staircase. Home to numerous wine bars, cellars and wineries, Würzburg is the center of the Franconian wine country, with its distinctive bocksbeutel (bottles with flattened round shapes).

Bamberg is a town in northern Bavaria, Germany, laid out over 7 hills where the Regnitz and Main rivers meet. Its old town preserves structures from the 11th to 19th centuries including the muraled Altes Rathaus (town hall), which occupies an island in the Regnitz reached by arched bridges. The Romanesque Bamberg Cathedral, begun in the 11th century, features 4 towers and numerous stone carvings.

Nuremberg is the largest city of the German federal state of Bavaria after its capital Munich, and its 518,370 inhabitants make it the 14th-largest city in Germany.