Rome is the capital city and a special comune of Italy, as well as the capital of the Lazio region. The city has been a major human settlement for almost three millennia. With 2,860,009 residents in 1,285 km², it is also the country's most populated comune.

Florence, capital of Italy’s Tuscany region, is home to many masterpieces of Renaissance art and architecture. One of its most iconic sights is the Duomo, a cathedral with a terracotta-tiled dome engineered by Brunelleschi and a bell tower by Giotto. The Galleria dell'Accademia displays Michelangelo’s “David” sculpture. The Uffizi Gallery exhibits Botticelli’s “The Birth of Venus” and da Vinci’s “Annunciation.”

Florence, capital of Italy’s Tuscany region, is home to many masterpieces of Renaissance art and architecture. One of its most iconic sights is the Duomo, a cathedral with a terracotta-tiled dome engineered by Brunelleschi and a bell tower by Giotto. The Galleria dell'Accademia displays Michelangelo’s “David” sculpture. The Uffizi Gallery exhibits Botticelli’s “The Birth of Venus” and da Vinci’s “Annunciation.”

The chic city of Monte Carlo in the petite kingdom of Monaco boasts some of the world’s most exclusive shopping and a beautiful old port. A fairy-tale aura has settled on this glittering city of the Grimaldi family, perhaps nowhere more elegantly than at the Prince’s Palace, where the late American actress-turned-princess Grace Kelly presided with Prince Rainier III. Monte Carlo’s medieval quarter perches on “The Rock,” an escarpment at the foot of the Maritime Alps, and offers spectacular views of the Mediterranean and the harbor lined with mega-yachts.

Marseille, a port city in southern France, has been a crossroads of immigration and trade since its founding by the Greeks circa 600 B.C. At its heart is the Vieux-Port (Old Port), where fishmongers sell their catch along the boat-lined quay. Basilique Notre-Dame-de-la-Garde is a Romanesque-Byzantine church. Modern landmarks include Le Corbusier’s influential Cité Radieuse complex and Zaha Hadid’s CMA CGM Tower

Barcelona, the cosmopolitan capital of Spain’s Catalonia region, is known for its art and architecture. The fantastical Sagrada Família church and other modernist landmarks designed by Antoni Gaudí dot the city. Museu Picasso and Fundació Joan Miró feature modern art by their namesakes. City history museum MUHBA, includes several Roman archaeological sites.

Barcelona, the cosmopolitan capital of Spain’s Catalonia region, is known for its art and architecture. The fantastical Sagrada Família church and other modernist landmarks designed by Antoni Gaudí dot the city. Museu Picasso and Fundació Joan Miró feature modern art by their namesakes. City history museum MUHBA, includes several Roman archaeological sites.

The port city of Valencia lies on Spain’s southeastern coast, where the Turia River meets the Mediterranean Sea. It’s known for its City of Arts and Sciences, with futuristic structures including a planetarium, an oceanarium and an interactive museum. Valencia also has several beaches, including some within nearby Albufera Park, a wetlands reserve with a lake and walking trails.

Seville is the capital of southern Spain’s Andalusia region. It's famous for flamenco dancing, particularly in its Triana neighborhood. Major landmarks include the ornate Alcázar castle complex, built during the Moorish Almohad dynasty, and the 18th-century Plaza de Toros de la Maestranza bullring. The Gothic Seville Cathedral is the site of Christopher Columbus’s tomb and a minaret turned bell tower, the Giralda.

Funchal is the capital city of Portugal's Madeira archipelago. It's backed by hills, and known for its harbor, gardens and Madeira wine cellars. The centuries-old Funchal Cathedral, which mixes Gothic and Romanesque styles, is notable for its carved wooden ceiling. Fronting the harbor is the São Tiago Fortress, built in the 1600s. It now houses the Contemporary Art Museum, with a large collection of Portuguese works.

Philipsburg is the capital of Sint Maarten, the Dutch side of the Caribbean island Saint Martin. Beachfront bars line the boardwalk along Great Bay. Voorstraat, or Front Street, has duty-free shops and casinos. The St. Maarten Zoo is home to parrots, monkeys and a playground. Sint Maarten Museum displays artifacts from the indigenous Arawak people. The ruins of 17th-century Fort Amsterdam stand on a nearby peninsula.