Venice, the capital of northern Italy’s Veneto region, is built on more than 100 small islands in a lagoon in the Adriatic Sea. It has no roads, just canals – including the Grand Canal thoroughfare – lined with Renaissance and Gothic palaces. The central square, Piazza San Marco, contains St. Mark’s Basilica, which is tiled with Byzantine mosaics, and the Campanile bell tower offering views of the city’s red roofs.

Venice, the capital of northern Italy’s Veneto region, is built on more than 100 small islands in a lagoon in the Adriatic Sea. It has no roads, just canals – including the Grand Canal thoroughfare – lined with Renaissance and Gothic palaces. The central square, Piazza San Marco, contains St. Mark’s Basilica, which is tiled with Byzantine mosaics, and the Campanile bell tower offering views of the city’s red roofs.

Šibenik is a city on the Adriatic coast of Croatia. It’s known as a gateway to the Kornati Islands. The 15th-century stone Cathedral of St. James is decorated with 71 sculpted faces. Nearby, the Šibenik City Museum, in the 14th-century Prince’s Palace, has exhibits ranging from prehistory to the present. The white stone St. Michael’s Fortress has an open-air theater, with views of Šibenik Bay and neighboring islands.

Bari is a port city on the Adriatic Sea, and the capital of southern Italy’s Puglia region. Its mazelike old town, Barivecchia, occupies a headland between 2 harbors. Surrounded by narrow streets, the 11th-century Basilica di San Nicola, a key pilgrimage site, holds some of St. Nicholas’ remains. To the south, the Murat quarter has stately 19th-century architecture, a promenade and pedestrianized shopping areas.

Crotone is a port city in Calabria, southern Italy. The monumental Castello di Carlo V is a 9th-century fortress that was modified in the 1500s. The National Archaeological Museum houses items, including a gold tiara, unearthed at the ancient Temple of Hera Lacinia in the nearby Capo Colonna Archaeological Park. Farther south is the Capo Rizzuto Marine Protected Area, with seagrass forests, barracudas and starfish

Sicily, the largest Mediterranean island, is just off the "toe" of Italy's "boot." Its rich history is reflected in sites like the Valley of the Temples, the well-preserved ruins of 7 monumental, Doric-style Greek temples, and in the Byzantine mosaics at the Cappella Palatina, a former royal chapel in capital city Palermo. On Sicily’s eastern edge is Mount Etna, one of Europe’s highest active volcanoes.

Naples, a city in southern Italy, sits on the Bay of Naples. Nearby is Mount Vesuvius, the still-active volcano that destroyed nearby Roman town Pompeii. Dating to the 2nd millennium B.C., Naples has centuries of important art and architecture. The city's cathedral, the Duomo di San Gennaro, is filled with frescoes. Other major landmarks include the lavish Royal Palace and Castel Nuovo, a 13th-century castle

Rome is the capital city and a special comune of Italy, as well as the capital of the Lazio region. The city has been a major human settlement for almost three millennia. With 2,860,009 residents in 1,285 km², it is also the country's most populated comune.

Florence, capital of Italy’s Tuscany region, is home to many masterpieces of Renaissance art and architecture. One of its most iconic sights is the Duomo, a cathedral with a terracotta-tiled dome engineered by Brunelleschi and a bell tower by Giotto. The Galleria dell'Accademia displays Michelangelo’s “David” sculpture. The Uffizi Gallery exhibits Botticelli’s “The Birth of Venus” and da Vinci’s “Annunciation.”

Florence, capital of Italy’s Tuscany region, is home to many masterpieces of Renaissance art and architecture. One of its most iconic sights is the Duomo, a cathedral with a terracotta-tiled dome engineered by Brunelleschi and a bell tower by Giotto. The Galleria dell'Accademia displays Michelangelo’s “David” sculpture. The Uffizi Gallery exhibits Botticelli’s “The Birth of Venus” and da Vinci’s “Annunciation.”

The chic city of Monte Carlo in the petite kingdom of Monaco boasts some of the world’s most exclusive shopping and a beautiful old port. A fairy-tale aura has settled on this glittering city of the Grimaldi family, perhaps nowhere more elegantly than at the Prince’s Palace, where the late American actress-turned-princess Grace Kelly presided with Prince Rainier III. Monte Carlo’s medieval quarter perches on “The Rock,” an escarpment at the foot of the Maritime Alps, and offers spectacular views of the Mediterranean and the harbor lined with mega-yachts.

Marseille, a port city in southern France, has been a crossroads of immigration and trade since its founding by the Greeks circa 600 B.C. At its heart is the Vieux-Port (Old Port), where fishmongers sell their catch along the boat-lined quay. Basilique Notre-Dame-de-la-Garde is a Romanesque-Byzantine church. Modern landmarks include Le Corbusier’s influential Cité Radieuse complex and Zaha Hadid’s CMA CGM Tower

Barcelona, the cosmopolitan capital of Spain’s Catalonia region, is known for its art and architecture. The fantastical Sagrada Família church and other modernist landmarks designed by Antoni Gaudí dot the city. Museu Picasso and Fundació Joan Miró feature modern art by their namesakes. City history museum MUHBA, includes several Roman archaeological sites.

Barcelona, the cosmopolitan capital of Spain’s Catalonia region, is known for its art and architecture. The fantastical Sagrada Família church and other modernist landmarks designed by Antoni Gaudí dot the city. Museu Picasso and Fundació Joan Miró feature modern art by their namesakes. City history museum MUHBA, includes several Roman archaeological sites.

Barcelona, the cosmopolitan capital of Spain’s Catalonia region, is known for its art and architecture. The fantastical Sagrada Família church and other modernist landmarks designed by Antoni Gaudí dot the city. Museu Picasso and Fundació Joan Miró feature modern art by their namesakes. City history museum MUHBA, includes several Roman archaeological sites.

Palma is a resort city and capital of the Spanish island of Mallorca (Majorca), in the western Mediterranean. The massive Santa María cathedral, a Gothic landmark begun in the 13th century, overlooks the Bay of Palma. The adjacent Almudaina is a Moorish-style Arab fortress converted to a royal residence. West of the city, hilltop Bellver Castle is a medieval fortress with a distinctive circular shape

Málaga is a port city on southern Spain’s Costa del Sol, known for its high-rise hotels and resorts jutting up from yellow-sand beaches. Looming over that modern skyline are the city’s 2 massive hilltop citadels, the Alcazaba and ruined Gibralfaro, remnants of Moorish rule. The city's soaring Renaissance cathedral is nicknamed La Manquita ("one-armed lady") because one of its towers was curiously left unbuilt

Seville is the capital of southern Spain’s Andalusia region. It's famous for flamenco dancing, particularly in its Triana neighborhood. Major landmarks include the ornate Alcázar castle complex, built during the Moorish Almohad dynasty, and the 18th-century Plaza de Toros de la Maestranza bullring. The Gothic Seville Cathedral is the site of Christopher Columbus’s tomb and a minaret turned bell tower, the Giralda.

Lisbon is Portugal’s hilly, coastal capital city. From imposing São Jorge Castle, the view encompasses the old city’s pastel-colored buildings, Tagus Estuary and Ponte 25 de Abril suspension bridge. Nearby, the National Azulejo Museum displays 5 centuries of decorative ceramic tiles. Just outside Lisbon is a string of Atlantic beaches, from Cascais to Estoril.

Lisbon is Portugal’s hilly, coastal capital city. From imposing São Jorge Castle, the view encompasses the old city’s pastel-colored buildings, Tagus Estuary and Ponte 25 de Abril suspension bridge. Nearby, the National Azulejo Museum displays 5 centuries of decorative ceramic tiles. Just outside Lisbon is a string of Atlantic beaches, from Cascais to Estoril.