Panama City, the capital of Panama, is a modern city framed by the Pacific Ocean and man-made Panama Canal. Casco Viejo, its cobblestoned historic center, is famed for colonial-era landmarks like the neoclassical Palacio Presidencial and bougainvillea-filled plazas lined with cafes and bars. The Miraflores Locks offers views of ships traversing the canal, an essential shipping route linking the Atlantic and Pacific.

Darién National Park is a world heritage site in Panama. It is about 325 kilometers from Panama City, and is the most extensive of all national parks of Panama and is one of the most important world heritage sites in Central America. The Darién National Park is a natural bridge spanning North and South America.

The Utría National Natural Park is a national park in the Chocó Department, Colombia. It contains diverse flora and fauna in a lush, mountainous rainforest environment with some of the highest rainfall in the world, at up to 10,000 millimetres annually.

Manta is a port city on Ecuador's central coast. It's known for its tuna-fishing industry. The popular Murciélago Beach is on the city's northwestern tip. Bars and restaurants are clustered along the Malecón Escénico promenade and nearby streets. The low-key Tarqui Beach has a waterside fish market. Nearby, the Central Bank Museum contains pre-Columbian relics from indigenous tribes.

Salaverry is a port town located 14 kilometres southeast of Trujillo city in the La Libertad Region, Peru. It is the capital of Salaverry District and it is located at around 8°13′16″S 78°58′34″W. The port, rebuilt in the 1960s by an English company, is able to accommodate large cruise ships.

Paracas is a town on Peru's west coast. It's known for beaches, like El Chaco, set on sheltered Paracas Bay. The town is a launch point for the uninhabited Ballestas Islands, home to sea lions, pelicans and Humboldt penguins. Rugged, wildlife-rich Paracas National Reserve spans desert, ocean, islands and the Paracas Peninsula. The peninsula’s Paracas Candelabra is a huge prehistoric geoglyph, etched into a hillside.

Valparaíso is a port city on Chile’s coast. It's known for its steep funiculars and colorful, clifftop homes. La Sebastiana, the quirky former residence of Chilean poet Pablo Neruda, is now a museum with far-reaching Pacific views. During the 19th century, an influx of European immigrants left their mark on the city’s architecture and cultural institutions, many of which congregate around downtown’s Plaza Sotomayor.