Istanbul to Rome (Civitavecchia), 2 Oct 2026 (14 nights)


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Bridging both Europe and Asia Minor, Istanbul is literally where “East meets West.” The city was founded by Constantine the Great and the history of this capital dates back sixteen centuries to the powerful Byzantine and Ottoman Empires. Many of our voyages include overnight stays in this legendary city, allowing more time to explore Istanbul’s highlights. Shop among the winding byways of the Grand Bazaar and the exotic stalls of the Spice Bazaar. Tour the magnificent courtyards of Topkapi Palace, stroll among the treasures of the Blue Mosque with its unique six minarets, then view Dolmabahce Palace, the one-time residence of the sultans. Or you may cruise along the Bosphorus for a unique perspective of the city’s numerous seaside mansions, mosques and palaces.
Soak up the scenery in Turkey's third largest city, Izmir. Meander along the relaxing Kordonboyu oceanfront promenade. Enjoy fresh, perfectly grilled sea bass as you look out over the beautiful harbor. Try one of Izmir’s delicious shish kebabs or a traditional kumru sandwich as you head off to explore its beautiful beaches. Visit the historic Kemeralti Market or the Kizlaragasi Bazaar, which happens to be one of the oldest bazaars in the city, dating from the 18th century Ottoman period.
Steeped in Greek mythological history, Mykonos was named after Apollo’s grandson, Mykons, and was the location of the grand battle between Zeus and the Gigantes. Today, this island is one of Greece’s most adored destinations due to its picture- postcard setting and growing nightlife. Mykonos is a superb example of Cycladic architecture, and by law even new buildings have to be built in the same style of whitewashed, organic, cube-like buildings. Be sure to plan a day trip to take in picturesque Little Venice, the unique Paraportiani church, and the archeological dig at Delos.
Piraeus is the gateway to the ancient city of Athens, known as the “Cradle of Western Civilization” because of its immense impact on cultural and political achievements throughout the world. Due mainly to tourism and the 2004 Olympics, Greece has redeveloped many sites in Athens. A historian’s delight, Athens is home to such magnificent wonders as: the Acropolis, the Parthenon, the atmospheric winding streets of the Plaka, Temple of Olympian Zeus and Temple of Athena Nike, and the Archaeological Museum with the world’s finest collection of ancient artifacts. Shore excursions on the first and last day of a cruise are only available for guests who are combining back-to-back voyages to create a longer cruise. Those guests may organize custom tours through the Destination Services Desk on board
Visit the great Minoan ruins of the Palace of Knossos, famous as the home of the labyrinth where the Minotaur roamed, and the Archaeological Museum housing many superb artifacts from the complex. Explore the stunning mountain-fringed Lassithi plateau with its orchards, 7000 windmills and ancient villages. Take home fine reproduction Minoan pottery, a traditional Cretan knife, local embroidery, hand-woven rugs, gold and silver jewelry. Relax over a dish of hearty moussaka or delicious souvlaki in a taverna, washed down with local wine or beer.
Egypt’s second largest city and chief harbor was built in 332BC by Alexander the Great. As new technology augments exploration capabilities, columns and statuary from its glorious past are still being recovered from Alexandria’s bay. Discover the city’s intriguing past at the Roman Catacombs of Kom El Shuquafa, Pompey’s Pillar, the Roman Theater, and the Citadel of Quait Bay, built on the foundation of the ancient Pharos Lighthouse, one of the Seven Wonders of the ancient world. Walk among the fragrent splendor of the Montaza Gardens, with 115 acres of lush, botanical beauty.
Egypt’s second largest city and chief harbor was built in 332BC by Alexander the Great. As new technology augments exploration capabilities, columns and statuary from its glorious past are still being recovered from Alexandria’s bay. Discover the city’s intriguing past at the Roman Catacombs of Kom El Shuquafa, Pompey’s Pillar, the Roman Theater, and the Citadel of Quait Bay, built on the foundation of the ancient Pharos Lighthouse, one of the Seven Wonders of the ancient world. Walk among the fragrent splendor of the Montaza Gardens, with 115 acres of lush, botanical beauty.
Malta’s major port and capital, the entire city of Valletta was inscribed as a UNESCO World Heritage Site in 1980. The centerpiece is the impressive 19th century Mosta Dome, visible from anywhere on the island, with its inlaid marble floor and the gilded, carved stone flowers set around the interior dome. For a tranquil afternoon, stroll the San Anton Palace Gardens, artistically laid out in Three Villages - Attard, Lija and Balzan. Or, for spectacular vistas, take a day tour to Dingli Cliffs, which offer striking views of the sea and rugged coastline. Valetta is also a portal to day trips to nearby Mdina, with its landmark Baroque Cathedral of St. John; and Rabat, the provincial township that was once part of the Roman city of Melita, where you can explore several fascinating archaeological digs.
Messina, the third largest city in Sicily, was the most important port of departure for European knights on their way to the Crusades in the Middle Ages. Today, this extensively rebuilt port city still boasts many historically and architecturally significant landmarks, particularly the renowned cathedral with its unusual astronomical clock, the 12th century Catania Church and the ornate Teatro Vittorio Emanuele. Messina is also the starting point for a day trip to the peak of breath-taking Mt. Etna-Crateri Silvestri.
Salerno is a port city southeast of Naples, in Italy. Atop Monte Bonadies, the centuries-old Arechi Castle has sea views, plus Museo Medievale del Castello, exhibiting medieval ceramics and coins. In town, built on the ruins of a Roman temple, is Salerno Cathedral. It has Byzantine bronze doors, a baroque crypt and a marble altar. The terraced Minerva’s Garden has been growing medicinal plants since the 14th century.
Whether enjoying the street performers at the Spanish Steps and people-watching over a fine glass of wine in colorful Trastevere, or taking in the historical and architectural glory that is Rome, visitors are spoiled for choice in this truly Eternal City. St. Peter’s Basilica is a full-day outing, featuring the Sistine Chapel and panoramic city vistas for those willing to climb to the top of the dome. Other landmarks not to miss include the renowned Trevi Fountain, the Coliseum, and Aventine Hill, which provides you with a grand view of the imposing remains of the Imperial Palaces and the Circus Maximus, of Ben Hur fame.
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Fare overview
This sailing is shown as a cruise-only guide fare with Regent Seven Seas Cruises. The fare is linked to the ship, itinerary and cabin category you choose. Drinks packages, gratuities, Wi-Fi, flights, transfers and shore experiences are only treated as included where they are confirmed before booking.

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Seven Seas Navigator
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Serene ocean views enhance the soothing color palette in each Seven Seas Navigator suite. You’ll also find luxurious bath amenities, a cozy robe and our superior Elite Slumber beds to ensure a relaxing and revitalizing voyage.
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