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Panama Canal Holiday Cruise: Miami, Cabo Rojo & San Diego

Azamara · Azamara Quest

Depart

Dec 18, 2026

Return

Jan 5, 2027

Port

Miami, Florida

Nights

18 nights

Azamara Quest at sea

At a glance

Built
2007
Tonnage
30277
Cabins
355
Crew
408

Your boutique hotel at sea, the Azamara Quest is a mid-sized ship with a deck plan that’s intimate but never crowded, and offers everything modern voyagers are looking for—plus some unexpected extras. Across the fleet, our authentic service goes beyond the expectations of even the most well-traveled cruisers. Friendly and approachable, our staff are attentive, and happy to offer everything from poolside service to recommendations for your on-shore exploration.

Ask our cruise specialists about cruise line loyalty benefits, status match options, drinks packages, gratuities and any current offers available on this sailing.

On board

Aqualina Restaurant

Aqualina Restaurant

Onboard Dining

Onboard Dining

Restaurant

Restaurant

Itinerary

Route map for Cruise from Miami, Florida to San Francisco, CaliforniaMiamiSan FranciscoCartagena, ColombiaPuerto QuetzalPuerto VallartaSan Diego
Day 1-19

Cruise from Miami, Florida to San Francisco, California

  1. Day 1MiamiDec 18, 2026 • Departs at: 5 pm

    Propelled by Latin rhythms, with a bold style all its own, Miami is a spicy melting pot of cultures. Immerse yourself in the colorful Art Deco district, vibrant nightlife, and beaches for sun-worshipers and water sport enthusiasts alike. Put some money on the horses at Hialeah Park, one of racings oldest and most prominent tracks, right next to a lake full of pink flamingos. Go adventuring in the Everglades, looking for ‘gators and manatees, canoeing through mangrove tunnels, or paddling a sea kayak through the “10,000 islands”. Flashy and full of life, it’s a great place to play.

  2. Day 2At SeaDec 19, 2026
  3. Day 3At SeaDec 20, 2026
  4. Day 4Cabo RojoDec 21, 2026 • Arrives at: 8 am • Departs at: 6 pm
  5. Day 5At SeaDec 22, 2026
  6. Day 6Cartagena, ColombiaDec 23, 2026 • Arrives at: 7 am • Departs at: 1 pm

    As a UNESCO World Heritage Site, Cartagena is an historic city undergoing a modern renaissance. Filled with legends, romance and splendor, the walled city features Spanish colonial architecture, cobblestone streets and cultural sites. Marvel at the Castle of San Felipe de Barajas, the Palace of the Inquisition, and the Clock Tower; explore the Squares of Los Coches, Santo Domingo, and Centenario; visit the beaches of Islas del Rosario National Park; or simply relax at one of the city’s many open-air cafés, as horse-drawn carriages parade by. No matter what you do, you’ll be enchanted by Cartagena and its people.

  7. Day 7Panama Canal (Cruising)Dec 24, 2026 • Arrives at: 5 am • Departs at: 5 pm
  8. Day 8At SeaDec 25, 2026
  9. Day 9Puntarenas, Costa RicaDec 26, 2026 • Arrives at: 8 am • Departs at: 8 pm

    With its coastline filled with beaches, islands, inlets and natural treasures, Puntarenas is a gateway to a myriad of outdoor attractions, including boat trips through the mangroves, canopy zip line tours, butterfly gardens, horseback riding, and sport fishing. Take a catamaran to the nearby Isla of Tortuga for its white sand beaches, snorkeling and swimming, go river rafting down the Corobici River, or explore the Mangrove Forest on the north side of the peninsula to see crocodiles, herons, and more. Be sure to take a stroll along the Paseo de la Turistas for shopping, souvenirs, local ceviche or a cold beverage, and pick up some Costa Rican coffee for the journey home.

  10. Day 10At SeaDec 27, 2026
  11. Day 11Puerto QuetzalDec 28, 2026 • Arrives at: 8 am • Departs at: 4 pm

    As Guatemala’s largest Pacific port, Puerto Quetzal is both an important cargo destination for the country and the main gateway to an array of outdoor activities and sightseeing adventures. Visit nearby Iztapa for tuna and marlin fishing, take a tour of a coffee or sugar cane plantation, or unwind at the beach in Balneario Likín, a popular Guatemalan resort town. But a definite highlight at this port is taking a day trip to the UNESCO World Heritage site of Antigua. Dating back to the 1500s, this stunning town nestled between volcanic peaks and located 4,500 feet above sea level, is renowned for its Spanish Baroque-influenced architecture, colonial churches and incredible views.

  12. Day 12At SeaDec 29, 2026
  13. Day 13At SeaDec 30, 2026
  14. Day 14Puerto VallartaDec 31, 2026 • Arrives at: 9 am • Departs at: 11 pm

    Located on the Pacific Coast of Mexico, and surrounded by the Sierra Madre Mountains and Banderas Bay, Puerto Vallarta has been a popular resort town for decades. Its subtropical climate, gentle breezes and turquoise blue waters—combined with award-winning restaurants and vibrant nightlife—makes Puerto Vallarta a picture-perfect destination, whether you’re looking for sun, sand and surf or a night on the town. The beaches are legendary, including Playa de Oro (Gold Beach), Los Muertos, and the famed Mismaloya Beach, where John Huston shot the film The Night of the Iguana. Head to historic Old Town for galleries and sculptures, and go for a stroll along the Malecón for more art, cafes, bars, and people watching.

  15. Day 15At SeaJan 1, 2027
  16. Day 16At SeaJan 2, 2027
  17. Day 17San DiegoJan 3, 2027 • Arrives at: 3 pm • Departs at: 10 pm

    In addition to being home to a world-class zoo and aquarium, San Diego is a laid-back navy town that is the closest U.S. city to Mexico. Great Mexican/American cuisine, Spanish-inspired architecture and what some consider the best weather in North America, make San Diego a destination unto itself.

  18. Day 18At SeaJan 4, 2027
  19. Day 19San FranciscoJan 5, 2027 • Arrives at: 6:30 am

    One of the great cities of the world, San Francisco is a must visit for every traveler. With its year-round fresh produce and seafood, the city is a food lovers delight, featuring hundreds of international restaurants to choose from, while its destination neighborhoods like Fisherman’s Wharf, Union Square and Chinatown are equally renowned for their culinary options, cultural offerings and outstanding shopping. Take a ride on one of San Francisco’s historic cable cars over Nob Hill to Ghiradelli Square for fantastic views of the city and some world-famous chocolate, cruise out to Alcatraz, take a day trip to the award-winning wineries of Sonoma and Napa, or visit Golden Gate Park, and be sure to include a walk (or run) across the iconic Golden Gate Bridge.

Miami, FloridaMiamiAt SeaCabo RojoCartagena, ColombiaPanama Canal (Cruising)Puntarenas, Costa RicaPuerto QuetzalPuerto VallartaSan DiegoSan FranciscoSan Francisco, California

Cabin options

Compare the cabin types and onboard features shown for this sailing. Final price and availability are confirmed by our team when you inquire.

26 cabin grades listed for this sailing.

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