Rome to Istanbul
Oceania Cruises · Sirena
Depart
Nov 5, 2026
Return
Nov 12, 2026
Port
Civitavecchia, Rome
Nights
7 nights

At a glance
- Built
- 2019
- Tonnage
- 30277
- Cabins
- 349
- Crew
- 400
Elegant sister ship to charming Regatta, Insignia and Nautica, Oceania Cruises’ newest addition, Sirena embodies the most treasured elements of our celebrated fleet, and features a few highlights all her own. With the introduction of two culinary experiences, Sirena offers even more ways to savor The Finest Cuisine at Sea. Tuscan Steak, a new specialty restaurant, serves Italian favorites, succulent steaks and fresh seafood inspired by Toscana and Polo Grill.
Ask our cruise specialists about cruise line loyalty benefits, status match options, drinks packages, gratuities and any current offers available on this sailing.
On board

Lounge Bar

The Grand Bar
Itinerary
Cruise from Civitavecchia, Rome to Istanbul
Day 1Rome, (Civitavecchia)Nov 5, 2026 • Departs at: 5 pm
Travel to Rome and revel in the magnificent monuments, from the ancient Roman Forum and Coliseum to the splendor of St. Peter's Basilica with Michelangelo's Pietà and his breathtaking frescoes in the Sistine Chapel. Or enjoy a drive through the lush farmlands of the Roman countryside to lovely medieval Castelgandolfo.
Day 2Naples/PompeiiNov 6, 2026 • Arrives at: 7 am • Departs at: 6 pm
Spend a day exploring the fabulous ruins of ancient Pompeii or Herculaneum with their stunning temples, frescoes and mosaics. Explore fascinating Naples and its famed museums, visit charming Sorrento or take a boat trip to the beautiful Isle of Capri.
Day 3MessinaNov 7, 2026 • Arrives at: 7 am • Departs at: 7 pm
Visit beautiful Taormina and marvel at its famous Greek theater and the stunning view of Mount Etna. Explore lovely medieval Messina with its historic churches and the cathedral where it is rumored Richard the Lionheart worshipped in 1190. Or discover ancient Tyndaris, founded in 396 B.C., with its fine mosaics, Roman baths and impressive theater overlooking the sea.
Day 4VallettaNov 8, 2026 • Arrives at: 7 am • Departs at: 7 pm
Discover the myriad of cultural layers of Malta, from its amazing prehistoric temples at Tarxien to beautiful walled medieval Mdina, nearby Rabat, and Marsaxlokk, a colorful fishing village. Admire the stunning scenery and wander through imposing churches and down the streets of fortified towns where the Knights of St. John once held sway.
Day 5At SeaNov 9, 2026
Day 6Athens (Piraeus)Nov 10, 2026 • Arrives at: 7 am • Departs at: 5 pm
Climb up the magnificent Acropolis and stand in awe of the Parthenon, the beautiful temples and the view over Athens stretched out before you. See city highlights including the new and old Olympic stadiums. Journey to Cape Sounion and the temple of Poseidon overlooking the sea, or visit ancient Corinth and the narrow Corinth Canal cut through miles of solid rock.
Day 7Mitilini (Lesbos)Nov 11, 2026 • Arrives at: 7 am • Departs at: 2 pm
Explore this bustling city's ancient roots, and visit the huge castle perched on the hill - the beautiful Greek theater that the Romans repaired and then copied back in Rome! See the impressive Cathedral and the Church of St. Nicholas, converted from a mosque. Enjoy the Archaeological Museum or one of the fine art museums with collections of important works. Venture into the old quarter near the waterfront to enjoy the old Turkish mansions or into the countryside and discover quaint villages where time has stopped.
Day 8Cruise returns to IstanbulNov 12, 2026 • Arrives at: 8 am
Indulge your eyes and senses in this magnificent city astride two continents. Visit beautiful Topkapi Palace, the awesome Hagia Sophia and the impressive Blue Mosque. Cruise the Bosphorus to see the city and its surroundings from another perspective. Visit one of the many museums or stroll through the spice market and the famous Grand Bazaar.
Cabin options
Compare the cabin types and onboard features shown for this sailing. Final price and availability are confirmed by our team when you inquire.
16 cabin grades listed for this sailing.
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