10-Day Greek Isles: Istanbul Overnight with Santorini

No modern metropolis is more steeped in myth than Athens, Greece. From the gritty port of Piraeus—gateway to Greece’s fabled isles—to the Parthenon—eternal symbol of Western civilization—Athens has attracted adventurers and classicists for centuries. This heritage is still very much alive for modern visitors sightseeing in Athens: ancient stadiums and temples dwell alongside apartment blocks, modern performances are staged in the marble amphitheaters where Greek drama was born and millennia-old monuments are scattered in the archaeological park that circles the Acropolis. One of the world’s oldest maritime powers, Athens is blessed with a balmy climate and stunning coastline. The seaside suburbs of Athens are scalloped with sandy beaches, fancy yacht clubs and glamorous beach bars. While the Athenian lifestyle is known for late-night dinners and dancing until dawn, the city shines brightly by day in the bustling markets, lively cafés and fascinating museums that illuminate Greece's pa…

Informality rules on this sunny isle where pleasure-seekers from around the world come to play. Ramble along narrow streets past white-washed houses and blue-domed churches, bouganvillea-covered walls and thread-like, step-laden footpaths leading everywhere.

Blurring the line between east and west, Istanbul stands at the crossroads of two continents. The city's architecture is rivalled only by its spectacular natural setting on the Bosphorus Strait. See the Blue Mosque, the Topkapi Palace and the Byzantine Church of St Sophia. Take time to wander through the Grand Bazaar or the Spice Market and sample baklava and shish kebabs.

Blurring the line between east and west, Istanbul stands at the crossroads of two continents. The city's architecture is rivalled only by its spectacular natural setting on the Bosphorus Strait. See the Blue Mosque, the Topkapi Palace and the Byzantine Church of St Sophia. Take time to wander through the Grand Bazaar or the Spice Market and sample baklava and shish kebabs.

Your harbor on this island was created by a volcano in 1500 BC., and the effect is still explosive: steep cliffs rise from sea level, cubist white houses glow in the Aegean sun. Sample shore excursion: Panoramic Santor ni.

The port of Souda on the Aegean Sea is home to a Greek and NATO naval base and is located six kilometers (three miles) from Chania—the second-largest city on Crete, which itself is the largest of the Greek Islands. Once you’re in Chania, set your compass for the historic waterfront with its famous Venetian Harbor dating to the 14th century. Walk along the breakwater to the restored 500-year-old lighthouse for views that are particularly photogenic from late afternoon until sunset. The atmospheric tangle of streets that is Old Town is easily explored on foot, and you can stop at one of the many outdoor cafés for a bouyatsa (custard pastry) or a glass of Cretan red wine.Soúda can also be a jumping-off point for a visit to Rethymnon, located about 54 kilometers (33 miles) to the east. Shaped by centuries of invasion, namely by the Venetians and Turks, its Fortezza was built by the Venetians in the late 16th century and captured by the Ottomans in 1646. The Old Town has the same kind of a…

Messina's astrological clock is as much a man-made masterpiece as the road leading to Taormina, which canitlevers out of the rocky cliff face and stands on impossibly tall pylons. Leave it to the Italians to design a road that's both a thrill-ride and a feat of engineering! Once you're safely in Taormina, walk to the sublime Greco-Roman theatre that overlooks Naxos Bay and snow-capped Mt Etna, and spend some time on the Corso Umberto with a gelato firmly in hand.

When you embark on a cruise to Rome with Holland America Line you experience its bustling modernism along with its rich history. You can walk in the footsteps of emperors, have coffee in Renaissance piazzas and see contemporary art all in one afternoon. Your sightseeing time in Rome begins at the nearby port of Civitavecchia, a seaside town with roots that stretch back to the Etruscan era. Take note of the Forte Michelangelo (both Bramante and Michelangelo had a hand in its design), and the lungomare, a lively stretch along the sea with beach clubs, bars and restaurants. Once in the Eternal City you can fill your day with museums, churches, archaeological sites, traditional trattorias, artisan shops and, of course, gelato. The Colosseum and the Vatican Museums are Rome's superstar attractions, but there are plenty of quieter gems to explore. For food lovers there are the markets in Campo de' Fiori or the slightly farther flung Testaccio. The hip neighborhood of Monti, next to the Colo…