One of Europe’s most visually stunning cities, Barcelona balances the medieval intimacy of its Gothic Quarter with the grace and distinction of the wide boulevards in the Moderniste Eixample. It was the home of architect Antoni Gaudí, whose Sagrada Familia Cathedral, Park Güell and Casa Milà are the most profound statements of Modernisme. View the splendid works at the Picasso Museum and the Miro Foundation, or discover Barcelona’s passionate ambiance at a flamenco show.

There is something for everyone in Alicante. The historic Mediterranean port city is located in renowned Costa Blanca, within the region of Valencia. From outdoor cafés to white-sand beaches to museums that house rare masterpieces, this town has everything one would expect of a Mediterranean escape. Be sure to visit the picturesque town of Guadalest, one of the most unique destinations in all of Spain.

Malta’s major port and capital, the entire city of Valletta was inscribed as a UNESCO World Heritage Site in 1980. The centerpiece is the impressive 19th century Mosta Dome, visible from anywhere on the island, with its inlaid marble floor and the gilded, carved stone flowers set around the interior dome. For a tranquil afternoon, stroll the San Anton Palace Gardens, artistically laid out in Three Villages - Attard, Lija and Balzan. Or, for spectacular vistas, take a day tour to Dingli Cliffs, which offer striking views of the sea and rugged coastline. Valetta is also a portal to day trips to nearby Mdina, with its landmark Baroque Cathedral of St. John; and Rabat, the provincial township that was once part of the Roman city of Melita, where you can explore several fascinating archaeological digs.

Destroyed by an earthquake in the 17th century, Catania has been beautifully restored and offers ancient churches, castles and amphitheaters, lush gardens and lovely palazzos to explore. Tour the 13th century Ursino Castle, which was situated along the coast until earthquakes and volcanic eruptions transformed the landscape. Drive inland through picturesque villages and explore Villa Romana del Casale, a 4th century villa and UNESCO World Heritage Site containing a complex collection of Roman mosaics considered one of the finest in the Roman world.

Salerno is a port city southeast of Naples, in Italy. Atop Monte Bonadies, the centuries-old Arechi Castle has sea views, plus Museo Medievale del Castello, exhibiting medieval ceramics and coins. In town, built on the ruins of a Roman temple, is Salerno Cathedral. It has Byzantine bronze doors, a baroque crypt and a marble altar. The terraced Minerva’s Garden has been growing medicinal plants since the 14th century.

Livorno is an Italian port city on the west coast of Tuscany. It's known for its seafood, Renaissance-era fortifications and modern harbor with a cruise ship port. Its central Terrazza Mascagni, a waterside promenade with checkerboard paving, is the city's main gathering place. The bastions of the 16th-century Fortezza Vecchia face the harbor and open onto Livorno's canal-laced Venezia Nuova quarter.

Whether enjoying the street performers at the Spanish Steps and people-watching over a fine glass of wine in colorful Trastevere, or taking in the historical and architectural glory that is Rome, visitors are spoiled for choice in this truly Eternal City. St. Peter’s Basilica is a full-day outing, featuring the Sistine Chapel and panoramic city vistas for those willing to climb to the top of the dome. Other landmarks not to miss include the renowned Trevi Fountain, the Coliseum, and Aventine Hill, which provides you with a grand view of the imposing remains of the Imperial Palaces and the Circus Maximus, of Ben Hur fame.