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Msc Grand Voyages from Genoa

MSC Cruises · MSC Opera

Depart

Oct 31, 2026

Return

Nov 16, 2026

Port

Genoa, Italy

Nights

16 nights

MSC Opera at sea

At a glance

Built
2004
Tonnage
65591
Cabins
1071
Crew
721

With its impressive array of new features and facilities, MSC Opera is now even better equipped to satisfy the needs of our guests. We’ve added spacious new cabins with balconies offering superb panoramic views and we have enlarged the restaurant and buffet areas to serve up an even greater variety of culinary treats.

Ask our cruise specialists about cruise line loyalty benefits, status match options, drinks packages, gratuities and any current offers available on this sailing.

On board

L'Approdo Restaurant

L'Approdo Restaurant

La Caravella Restaurant

La Caravella Restaurant

Itinerary

Route map for Cruise from Genoa, Italy to La RomanaGenoa (Portofino), ItalyLa RomanaBarcelona
Day 1-17

Cruise from Genoa, Italy to La Romana

  1. Day 1Genoa (Portofino), ItalyOct 31, 2026 • Departs at: 6 pm

    Genoa is marvellously eclectic, vibrant and full of rough-edged style; it’s a great cruise excursion. Indeed “La Superba” (The Superb), as it was known at the height of its authority as a Mediterranean superpower, boasts more zest and intrigue than all the surrounding coastal resorts put together. During a holiday to Genoa you can explore its old town: a dense and fascinating warren of medieval alleyways home to large palazzi built in the sixteenth and seventeenth centuries by Genoa’s wealthy mercantile families and now transformed into museums and art galleries. You should seek out the Cattedrale di San Lorenzo, the Palazzo Ducale, and the Renaissance palaces of Via Garibaldi which contain the cream of Genoa’s art collections, as well as furniture and decor from the grandest days of the city’s past, when its ships sailed to all corners of the Mediterranean Sea. The Acquario di Genova is the city’s pride and joy, parked like a giant ocean liner on the waterfront, with seventy tanks ho…

  2. Day 2Marseille (Provence), FranceNov 1, 2026 • Arrives at: 8 am • Departs at: 6 pm

    On the spectacular coastline of the French Riviera lies Marseille, an MSC Mediterranean Cruises destination. This atmospheric port city is known for its unique mix of grit and glamour, seen in its labyrinth of streets and historical architecture. Only a few miles from Marseille’s charismatic cafes and bustling Vieux Port, stunning cities are to be found. Visit Aix-en-Provence, birthplace of Cézanne, or take in the ancient beauty of Avignon.

  3. Day 3BarcelonaNov 2, 2026 • Arrives at: 7 am • Departs at: 4 pm

    One of the busiest cruise ports in the Mediterranean, the seaside city of Barcelona is known for its iconic architecture, colourful culture, and world-class drinking and dining. Explore Antoni Gaudí’s surreal Sagrada Família, the famous boulevard of the Ramblas, the medieval Barri Gótic, and the Museu Picasso. But there’s even more to discover in this sprawling Spanish city, an MSC Mediterranean Cruises destination: from hidden tapas bars and fabulous food markets to Europe’s biggest football stadium.

  4. Day 4At SeaNov 3, 2026
  5. Day 5TangierNov 4, 2026 • Arrives at: 7 am • Departs at: 5 pm

    Settled on the Strait of Gibraltar, Tangier, an MSC Mediterranean Cruises destination, is an energetic and multicultural port. This magical Moroccan city is distinguished by its whitewashed Medina, maze of evocative alleys, bustling squares, and fascinating people. Glimpse the Dar el Makhzen palace, the Church of Saint Andrew, Jardins de la Mendoubia park, and the famous Bab Al Fahs gate. Further afield, visit natural wonders including the surreal Caves of Hercules.

  6. Day 6At SeaNov 5, 2026
  7. Day 7At SeaNov 6, 2026
  8. Day 8At SeaNov 7, 2026
  9. Day 9At SeaNov 8, 2026
  10. Day 10At SeaNov 9, 2026
  11. Day 11At SeaNov 10, 2026
  12. Day 12At SeaNov 11, 2026
  13. Day 13St. John s, Antigua and BarbudaNov 12, 2026 • Arrives at: 9 am • Departs at: 6 pm

    “One beach a day,” Antigua’s motto, refers to the island’s 365 beautiful beaches that are famous, secret or even set in volcanic craters. There’s a beach for every lifestyle, for those who are social and ones who seek solitude. When you arrive on an MSC Caribbean and Antilles cruise in the port of St. John’s, the capital and commercial centre of Antigua and Barbuda, embrace the city’s colourfully vi-brant houses dating to its British colonial period, along with the evocative white baroque towers of St. John's Cathedral, and the Fort James and Barrington fortresses. The laid-back cosmopolitan city, with its distinctly British flair, is renowned for its shopping at luxury boutiques and high-end shopping malls. Beyond the city, book an MSC excursion to the historic Nelson's Dockyard in English Harbour, dedicated to Admiral Horatio Nelson, who was stationed in the West Indies be-tween 1784 and 1787. The shipyard, a UNESCO World Heritage Site, is the largest of Antigua’s National Parks and…

  14. Day 14Philipsburg, St MaartenNov 13, 2026

    Offering some of the best vistas in all the Caribbean, St. Maarten is the smallest inhabited island in the world shared by two nations - France in the north and the Netherlands in the south. Dubbed the true melting pot of the Caribbean, the 37-square-mile island is home to people of 47 different nationalities and more than 400 restaurants, featuring a hugely diverse variety of cuisine. The island also has two capitals: Philipsburg on the Dutch side, and Marigot in the French part. Once you arrive on an MSC Caribbean and Antilles cruise in St. Maarten, explore how the two cultures have blended their very distinct characters on one of our MSC excursions. Your St. Maarten cruise will dock in Philipsburg, founded in 1763 by John Philips, a Scottish captain in the Dutch Navy. Philipsburg, with its pastel-coloured West Indian houses, is known for its duty-free shopping along Front Street, the Great Salt Pond, which once made the island literally “worth its salt,” and attracted the attention…

  15. Day 14Philipsburg, St MaartenNov 13, 2026

    Offering some of the best vistas in all the Caribbean, St. Maarten is the smallest inhabited island in the world shared by two nations - France in the north and the Netherlands in the south. Dubbed the true melting pot of the Caribbean, the 37-square-mile island is home to people of 47 different nationalities and more than 400 restaurants, featuring a hugely diverse variety of cuisine. The island also has two capitals: Philipsburg on the Dutch side, and Marigot in the French part. Once you arrive on an MSC Caribbean and Antilles cruise in St. Maarten, explore how the two cultures have blended their very distinct characters on one of our MSC excursions. Your St. Maarten cruise will dock in Philipsburg, founded in 1763 by John Philips, a Scottish captain in the Dutch Navy. Philipsburg, with its pastel-coloured West Indian houses, is known for its duty-free shopping along Front Street, the Great Salt Pond, which once made the island literally “worth its salt,” and attracted the attention…

  16. Day 15BasseterreNov 14, 2026 • Arrives at: 8 am • Departs at: 6 pm

    An MSC Caribbean and Antilles cruise to St. Kitts and Nevis will introduce you to the sister volcanic islands of the Caribbean. These islands have been a premier destination for elite tourists for more than 200 years and served as a haven for European nobility in the 19th and 20th centuries. Basseterre, founded by the French in 1625, became the capital of St. Kitts in 1727, when the Eng-lish took over the island. It remained under British rule until the islands declared their independence in 1983. Throughout the city’s long history, natural disasters and conflicts have afflicted Basseterre; most buildings date from the latter part of the 1800s. A visit to the city’s two cathedrals, St. George’s Anglican Church and the Catholic Cathedral of Immaculate Conception, will appeal to those with a love of history and architecture. On South Square Street, visit Georgian House, one of the better-preserved examples of local 18th-century architecture. Leaving Basseterre, take a panoramic drive on…

  17. Day 16At SeaNov 15, 2026
  18. Day 17Cruise returns to La RomanaNov 16, 2026 • Arrives at: 7 am

    La Romana is a city on the Dominican Republic’s Caribbean coast and a gateway to nearby resort areas. Overlooking the Chavón River, Altos de Chavón is a re-created 16th-century Mediterranean village with artists' workshops. An obelisk painted with colorful images of local life stands in the city center. South of the city is Catalina Island, with beaches, coral reefs and the wrecked ship of pirate William Kidd.

Genoa, ItalyGenoa (Portofino), ItalyMarseille (Provence), FranceBarcelonaAt SeaTangierSt. John s, Antigua and BarbudaPhilipsburg, St MaartenBasseterreLa Romana

Cabin options

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12 cabin grades listed for this sailing.

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