Cologne, a 2,000-year-old city spanning the Rhine River in western Germany, is the region’s cultural hub. A landmark of High Gothic architecture set amid reconstructed old town, the twin-spired Cologne Cathedral is also known for its gilded medieval reliquary and sweeping river views. The adjacent Museum Ludwig showcases 20th-century art, including many masterpieces by Picasso, and the Romano-Germanic Museum houses Roman antiquities.

Koblenz, spelled Coblenz before 1926, is a German city on the banks of the Rhine and of the Moselle, a multi-nation tributary. Koblenz was established as a Roman military post by Drusus around 8 B.C. Its name originates from the Latin cōnfluentēs, meaning " confluence"

Rüdesheim am Rhein is a town in the Rhine Valley, Germany. It’s known for winemaking, especially of Riesling wines. In the center, Drosselgasse is a lane lined with shops, taverns and restaurants. Nearby, Siegfried’s Mechanical Music Cabinet is a museum of automated musical instruments. Medieval Brömserburg Castle is home to the Rheingau Wine Museum, exhibiting wine paraphernalia from ancient times to the present.

Speyer is a city in Rhineland-Palatinate in Germany with approximately 50,000 inhabitants. Located on the left bank of the river Rhine, Speyer lies 25 km south of Ludwigshafen and Mannheim, and 21 km south-west of Heidelberg. Founded by the Romans, it is one of Germany's oldest cities.

Strasbourg is the capital city of the Grand Est region, formerly Alsace, in northeastern France. It's also the formal seat of the European Parliament and sits near the German border, with culture and architecture blending German and French influences. Its Gothic Cathédrale Notre-Dame features daily shows from its astronomical clock and sweeping views of the Rhine River from partway up its 142m spire.

Boppard, formerly also spelled Boppart, is a town and municipality in the Rhein-Hunsrück-Kreis in Rhineland-Palatinate, Germany, lying in the Rhine Gorge, a UNESCO World Heritage Site. The town is also a state-recognized tourism resort and is a winegrowing centre.

Cologne, a 2,000-year-old city spanning the Rhine River in western Germany, is the region’s cultural hub. A landmark of High Gothic architecture set amid reconstructed old town, the twin-spired Cologne Cathedral is also known for its gilded medieval reliquary and sweeping river views. The adjacent Museum Ludwig showcases 20th-century art, including many masterpieces by Picasso, and the Romano-Germanic Museum houses Roman antiquities.

Cologne, a 2,000-year-old city spanning the Rhine River in western Germany, is the region’s cultural hub. A landmark of High Gothic architecture set amid reconstructed old town, the twin-spired Cologne Cathedral is also known for its gilded medieval reliquary and sweeping river views. The adjacent Museum Ludwig showcases 20th-century art, including many masterpieces by Picasso, and the Romano-Germanic Museum houses Roman antiquities.