10-Day Greek Isles from Istanbul to Rome: Santorini, Athens & Mykonos

There's a new aura of excitement in Istanbul these days, as this centre of the Ottoman empire has become one the world's focal points for art, fashion, haute cuisine and nightlife. Of course there's always an abundance of ancient monuments and grand mosques with stunning frescoes to see here, like the Hagia Sophia and Blue Mosque. Head to any park and you'll see why tulips have long been the symbol of this city. Explore more of Istanbul on a European cruise!

Take a journey into the past in richly historic Ephesus. Once an ancient Greek city, Kusadasi was known for the famed Temple of Artemis, one of the Seven Wonders of the Ancient World. Built, destroyed, and rebuilt again through several notably historical periods, Ephesus boasts abounding ruins and archaeological excavation sites. View what remains of the Roman Library of Celsus, the Gate of Augustus, the Tomb of John the Apostle, and the Basilica of St. John, among several other ancient remnants.

Whitewashed villages clinging to the sides of the sea cliffs have made the volcanic island of Santorini one of the most widely photographed places in the world. The island's charm and subtle mystery have even made it a target of speculation as the location of the lost city of Atlantis.

Mykonos is a classic Greek Island with whitewashed houses, blue-domed churches and windmills. Add a reputation for beautiful beaches and you'll understand why Mykonos is the most popular island in the Cyclades. Explore the island in a 4 x 4 or take a ferry to the tiny island of Delos. Explore more of Mykonos on a European cruise!

This is the cradle of civilization, the oldest city in Europe. Not only is this city home to the Acropolis and some of the most important architectural structures and archaeological finds in the Western world, It is also a very modern city, an urban amalgam of extraordinary art, culture, cuisine and shopping. Explore more of Athens on a European cruise!

The ancient port city of Catania is situated in the shadow of the famous active volcano, Mount Etna, which dominates the landscape and is intertwined with the town's history. Steeped in a storied past, Catania's squares, cathedrals and other historic sites are a must-visit on a guided tour, as are its open-air markets and friendly cafes that offer a taste of modern life in the region. You can also journey outside Catania to explore the surrounding lava fields and unique rock formations or hike, bike or go off-roading on one of the trails crisscrossing the volcano for an unforgettable outdoor adventure.

The history of Salerno is as rich and vibrant as its surrounding landscapes. The site of ancient settlements (Neolithic mummy remains discovered here), Salerno has been home to vast empires and was the site of Medieval Europe's first medical school. A trip to Salerno makes it easy to understand why countless people have been drawn to its location along the Gulf of Salerno. Nestled between the mountains and the sea at the southeastern point of the famed Amalfi Coast, Salerno boasts sun-drenched beaches, nature reserves and parks, historic sites and delicious local cuisine.

Located along what's known as the Ligurian Riviera, La Spezia and its surrounding area are characterized by steep cliffs overlooking tranquil waters, quiet coves, dense forests and popular beaches. A busy port city that includes a major naval base, La Spezia is the second largest city in the province and is home to historic sites, interesting museums and no shortage of scenic overlooks. The city is considered the gateway to the famed Cinque Terre - a string of five centuries-old seaside villages that are one of the most picturesque regions of the Mediterranean. Spend the day uncovering the best of La Spezia or journey to Cinque Terre on a guided tour.

Endless adventures await in Rome. With two and a half thousand years of history, art and culture, it is no wonder Rome is one of the most visited cities on the planet. Gaze at the masterpieces of the Vatican or walk into the past with visits to ancient relics, historic monuments and legendary museums. Or people-watch while sipping on an espresso in a quaint cafe.