South America from San Antonio (Santiago), Chile

Ushuaia is a resort town in Argentina. It's located on the Tierra del Fuego archipelago, the southernmost tip of South America, nicknamed the “End of the World.” The windswept town, perched on a steep hill, is surrounded by the Martial Mountains and the Beagle Channel. It's the gateway to Antarctica cruises and tours to nearby Isla Yécapasela, known as “Penguin Island” for its penguin colonies.

Puerto Madryn is an Argentine city on the coast of northern Patagonia. Its sandy beaches and restaurant-lined promenade face Golfo Nuevo bay, where southern right whales breed from May to December. Ecocentro is a clifftop museum with exhibits on Patagonian nature, and a lighthouse-style tower for ocean views. Across the bay, rocky Valdes Peninsula is home to penguins and elephant seals, which are preyed on by orcas.

Montevideo, Uruguay’s capital, is a major city along Montevideo Bay. It revolves around the Plaza de la Independencia, once home to a Spanish citadel. This plaza leads to Ciudad Vieja (the old town), with art deco buildings, colonial homes and landmarks including the towering Palacio Salvo and neoclassical performance hall Solís Theatre. Mercado del Puerto is an old port market filled with many steakhouses.

Buenos Aires is Argentina’s big, cosmopolitan capital city. Its center is the Plaza de Mayo, lined with stately 19th-century buildings including Casa Rosada, the iconic, balconied presidential palace. Other major attractions include Teatro Colón, a grand 1908 opera house with nearly 2,500 seats, and the modern MALBA museum, displaying Latin American art