Cologne, a 2,000-year-old city spanning the Rhine River in western Germany, is the region’s cultural hub. A landmark of High Gothic architecture set amid reconstructed old town, the twin-spired Cologne Cathedral is also known for its gilded medieval reliquary and sweeping river views. The adjacent Museum Ludwig showcases 20th-century art, including many masterpieces by Picasso, and the Romano-Germanic Museum houses Roman antiquities.

Koblenz, spelled Coblenz before 1926, is a German city on the banks of the Rhine and of the Moselle, a multi-nation tributary. Koblenz was established as a Roman military post by Drusus around 8 B.C. Its name originates from the Latin cōnfluentēs, meaning " confluence"

Mainz is a German city on the Rhine River. It’s known for its old town, with half-timbered houses and medieval market squares. In the center, the Marktbrunnen is a Renaissance fountain with red columns. Nearby, a distinctive octagonal tower tops the Romanesque Mainz Cathedral, built of deep red sandstone. The Gutenberg Museum honors the inventor of the printing press with exhibits, including 2 of his original bibles

Miltenberg is a town in the Regierungsbezirk of Lower Franconia in Bavaria, Germany. It is the seat of the like-named district and has a population of over

Würzburg is a city in Germany's Bavaria region. It's known for lavish baroque and rococo architecture, particularly the 18th-century Residenz palace, with ornate rooms, a huge fresco by Venetian artist Tiepolo and an elaborate staircase. Home to numerous wine bars, cellars and wineries, Würzburg is the center of the Franconian wine country, with its distinctive bocksbeutel (bottles with flattened round shapes).

Bamberg is a town in northern Bavaria, Germany, laid out over 7 hills where the Regnitz and Main rivers meet. Its old town preserves structures from the 11th to 19th centuries including the muraled Altes Rathaus (town hall), which occupies an island in the Regnitz reached by arched bridges. The Romanesque Bamberg Cathedral, begun in the 11th century, features 4 towers and numerous stone carvings.

Nuremberg is the second-largest city of the German state of Bavaria after its capital Munich, and its 518,370 inhabitants make it the 14th-largest city in Germany.

Regensburg, a Bavarian city on the Danube River in southeast Germany, is known for its well-preserved medieval core. The 12th-century Stone Bridge, a 310m-long icon with 16 arches, crosses the river to the old town. The 13th-century Regensburg Cathedral, a twin-spired Gothic landmark, is home to the Regensburger Domspatzen choir. Walhalla, a Parthenon replica just east of the city, honors illustrious Germans.

Passau, a German city on the Austrian border, lies at the confluence of the Danube, Inn and Ilz rivers. Known as the Three Rivers City, it's overlooked by the Veste Oberhaus, a 13th-century hilltop fortress housing a city museum and observation tower. The old town below is known for its baroque architecture, including St. Stephen's Cathedral, featuring distinctive onion-domed towers and an organ with 17,974 pipes.

Melk is an Austrian town on the River Danube, west of Vienna. It’s known for the 11th-century Melk Abbey, a vast monastery built high above the town. Gold statuary adorns its domed Abbey Church, and the huge library houses medieval manuscripts. The Marmorsaal is a baroque hall with a ceiling fresco and red marble walls. South of Melk, gardens surround Renaissance Schallaburg Castle, which hosts cultural exhibitions.

Vienna, Austria’s capital, lies in the country’s east on the Danube River. Its artistic and intellectual legacy was shaped by residents including Mozart, Beethoven and Sigmund Freud. The city is also known for its Imperial palaces, including Schönbrunn, the Habsburgs’ summer residence. In the MuseumsQuartier district, historic and contemporary buildings display works by Egon Schiele, Gustav Klimt and other artists.

Bratislava, the capital of Slovakia, is set along the Danube River by the border with Austria and Hungary. It’s surrounded by vineyards and the Little Carpathian mountains, crisscrossed with forested hiking and cycling trails. The pedestrian-only, 18th-century old town is known for its lively bars and cafes. Perched atop a hill, the reconstructed Bratislava Castle overlooks old town and the Danube.

Budapest, Hungary’s capital, is bisected by the River Danube. Its 19th-century Chain Bridge connects the hilly Buda district with flat Pest. A funicular runs up Castle Hill to Buda’s Old Town, where the Budapest History Museum traces city life from Roman times onward. Trinity Square is home to 13th-century Matthias Church and the turrets of the Fishermen’s Bastion, which offer sweeping views. ―

Budapest, Hungary’s capital, is bisected by the River Danube. Its 19th-century Chain Bridge connects the hilly Buda district with flat Pest. A funicular runs up Castle Hill to Buda’s Old Town, where the Budapest History Museum traces city life from Roman times onward. Trinity Square is home to 13th-century Matthias Church and the turrets of the Fishermen’s Bastion, which offer sweeping views. ―