25 nights South Caribbean from Civitavecchia (Rome)
MSC Cruises · MSC Opera
Depart
Oct 29, 2026
Return
Nov 23, 2026
Port
Civitavecchia, Rome
Nights
25 nights

At a glance
- Built
- 2004
- Tonnage
- 65591
- Cabins
- 1071
- Crew
- 721
With its impressive array of new features and facilities, MSC Opera is now even better equipped to satisfy the needs of our guests. We’ve added spacious new cabins with balconies offering superb panoramic views and we have enlarged the restaurant and buffet areas to serve up an even greater variety of culinary treats.
Ask our cruise specialists about cruise line loyalty benefits, status match options, drinks packages, gratuities and any current offers available on this sailing.
On board

L'Approdo Restaurant

La Caravella Restaurant
Itinerary
Cruise from Civitavecchia, Rome to La Romana
Day 1Civitavecchia (Rome), ItalyOct 29, 2026 • Departs at: 7 pm
Discover the culture and colour of Civitavecchia, an MSC Mediterranean Cruises destination. This Italian gem is an enjoyable flight from many European and non-European cities. Celebrated for its 16th-century Michelangelo Fort, ancient Taurine Baths, and marble Vanvitelli fountain, the port is a convenient starting point for visiting Rome, Italy’s regal and romantic capital.
Day 2Genoa (Portofino), ItalyOct 30, 2026 • Arrives at: 8 am • Departs at: 6 pm
Genoa is marvellously eclectic, vibrant and full of rough-edged style; it’s a great cruise excursion. Indeed “La Superba” (The Superb), as it was known at the height of its authority as a Mediterranean superpower, boasts more zest and intrigue than all the surrounding coastal resorts put together. During a holiday to Genoa you can explore its old town: a dense and fascinating warren of medieval alleyways home to large palazzi built in the sixteenth and seventeenth centuries by Genoa’s wealthy mercantile families and now transformed into museums and art galleries. You should seek out the Cattedrale di San Lorenzo, the Palazzo Ducale, and the Renaissance palaces of Via Garibaldi which contain the cream of Genoa’s art collections, as well as furniture and decor from the grandest days of the city’s past, when its ships sailed to all corners of the Mediterranean Sea. The Acquario di Genova is the city’s pride and joy, parked like a giant ocean liner on the waterfront, with seventy tanks ho…
Day 3Livorno(Florence), ItalyOct 31, 2026 • Arrives at: 8 am • Departs at: 6 pm
On the west coast of Tuscany lies the cosmopolitan port city of Livorno, an MSC Mediterranean Cruises destination. This Italian getaway is known for its historical architecture, sumptuous seafood, and checkboard waterside promenade. Livorno is the perfect launch pad for visiting Tuscany’s beautiful art cities, Florence and Pisa. What’s more, you’ll find great natural environments, like Macchia della Magona, spread across the region.
Day 4Marseille (Provence), FranceNov 1, 2026 • Arrives at: 9 am • Departs at: 6 pm
On the spectacular coastline of the French Riviera lies Marseille, an MSC Mediterranean Cruises destination. This atmospheric port city is known for its unique mix of grit and glamour, seen in its labyrinth of streets and historical architecture. Only a few miles from Marseille’s charismatic cafes and bustling Vieux Port, stunning cities are to be found. Visit Aix-en-Provence, birthplace of Cézanne, or take in the ancient beauty of Avignon.
Day 5BarcelonaNov 2, 2026 • Arrives at: 7 am • Departs at: 4 pm
One of the busiest cruise ports in the Mediterranean, the seaside city of Barcelona is known for its iconic architecture, colourful culture, and world-class drinking and dining. Explore Antoni Gaudí’s surreal Sagrada Família, the famous boulevard of the Ramblas, the medieval Barri Gótic, and the Museu Picasso. But there’s even more to discover in this sprawling Spanish city, an MSC Mediterranean Cruises destination: from hidden tapas bars and fabulous food markets to Europe’s biggest football stadium.
Day 6At SeaNov 3, 2026
Day 7TangierNov 4, 2026 • Arrives at: 8 am • Departs at: 5 pm
Settled on the Strait of Gibraltar, Tangier, an MSC Mediterranean Cruises destination, is an energetic and multicultural port. This magical Moroccan city is distinguished by its whitewashed Medina, maze of evocative alleys, bustling squares, and fascinating people. Glimpse the Dar el Makhzen palace, the Church of Saint Andrew, Jardins de la Mendoubia park, and the famous Bab Al Fahs gate. Further afield, visit natural wonders including the surreal Caves of Hercules.
Day 8At SeaNov 5, 2026
Day 9At SeaNov 6, 2026
Day 10At SeaNov 7, 2026
Day 11At SeaNov 8, 2026
Day 12At SeaNov 9, 2026
Day 13At SeaNov 10, 2026
Day 14At SeaNov 11, 2026
Day 15St John's, New Foundland, CanadaNov 12, 2026 • Arrives at: 9 am • Departs at: 6 pm
A One-of-a-Kind Natural Microcosm Wild landscapes, valleys dotted with farms, fishing villages, parks and islands all along the coast: all of this and more awaits you in New Brunswick, a beautiful maritime province in French Canada. Your MSC cruise will take you on the discovery of a natural land filled with a thousand secrets, surprising you with its magnificent coastline, mountains, forests and rivers, as well as the variety of wild animals that live there including bears, whales, moose and seals. This region is home to one of the oldest cities in Canada overlooking the beautiful Bay of Fundy: Saint John. There is no other place in the Maritimes with the same urban charm of a historic city balanced with the grandiose, natural charm of a bay famous for its impressive tides. On your MSC cruise, you will have a chance to discover this port city with its delightful Victorian architecture and steep historical streets, watch the ships dock at the port and admire the restaurants and shops…
Day 16Philipsburg, St MaartenNov 13, 2026 • Arrives at: 9 am • Departs at: 6 pm
Offering some of the best vistas in all the Caribbean, St. Maarten is the smallest inhabited island in the world shared by two nations - France in the north and the Netherlands in the south. Dubbed the true melting pot of the Caribbean, the 37-square-mile island is home to people of 47 different nationalities and more than 400 restaurants, featuring a hugely diverse variety of cuisine. The island also has two capitals: Philipsburg on the Dutch side, and Marigot in the French part. Once you arrive on an MSC Caribbean and Antilles cruise in St. Maarten, explore how the two cultures have blended their very distinct characters on one of our MSC excursions. Your St. Maarten cruise will dock in Philipsburg, founded in 1763 by John Philips, a Scottish captain in the Dutch Navy. Philipsburg, with its pastel-coloured West Indian houses, is known for its duty-free shopping along Front Street, the Great Salt Pond, which once made the island literally “worth its salt,” and attracted the attention…
Day 17BasseterreNov 14, 2026 • Arrives at: 8 am • Departs at: 6 pm
An MSC Caribbean and Antilles cruise to St. Kitts and Nevis will introduce you to the sister volcanic islands of the Caribbean. These islands have been a premier destination for elite tourists for more than 200 years and served as a haven for European nobility in the 19th and 20th centuries. Basseterre, founded by the French in 1625, became the capital of St. Kitts in 1727, when the Eng-lish took over the island. It remained under British rule until the islands declared their independence in 1983. Throughout the city’s long history, natural disasters and conflicts have afflicted Basseterre; most buildings date from the latter part of the 1800s. A visit to the city’s two cathedrals, St. George’s Anglican Church and the Catholic Cathedral of Immaculate Conception, will appeal to those with a love of history and architecture. On South Square Street, visit Georgian House, one of the better-preserved examples of local 18th-century architecture. Leaving Basseterre, take a panoramic drive on…
Day 18At SeaNov 15, 2026
Day 19La RomanaNov 16, 2026 • Arrives at: 7 am • Departs at: 11:30 pm
La Romana is a city on the Dominican Republic’s Caribbean coast and a gateway to nearby resort areas. Overlooking the Chavón River, Altos de Chavón is a re-created 16th-century Mediterranean village with artists' workshops. An obelisk painted with colorful images of local life stands in the city center. South of the city is Catalina Island, with beaches, coral reefs and the wrecked ship of pirate William Kidd.
Day 20Catalina IslandNov 17, 2026 • Arrives at: 7 am • Departs at: 5 pm
Day 21At SeaNov 18, 2026
Day 22Bridgetown, BarbadosNov 19, 2026 • Arrives at: 9 am • Departs at: 7 pm
When you arrive in Barbados on an MSC Caribbean and Antilles cruise, begin your exploration with the capital, Bridgetown. There are many attractions in this small Caribbean city, but by all means pause to admire its many colonial buildings, the Parliament Building and the statue of Lord Nelson standing in what is currently called the National Heroes Square. Barbados has retained somewhat of a British feel, with its place names, cricket, horse-racing and polo, Anglican parish churches and even a hilly district known as Scotland. But the Britishness can be exaggerated, for this is a distinctly West Indian country, covered by a patch-work of sugarcane fields and dotted with tiny rum shops. The Garrison Historic Area, a UNESCO World Heritage Site with magnificent 18th- and 19th-century buildings, is a must-see stop, featuring one of the world's finest collection of cannons. It also includes the George Washington House, where the American patriot spent six weeks of his life. The current St…
Day 23Fort de France, MartiniqueNov 20, 2026 • Arrives at: 8 am • Departs at: 7 pm
Thanks in large part to its French and West Indian influences, Martinique, a lush mountainous island in the Lesser Antilles with its dormant Mount Pelée volcano in the backdrop, exudes a cosmopolitan flair with a sophisticated culinary and cultural scene that draws travellers not only to its natural wonders, beautiful bays and beaches, but also to its heart at Fort-de-France, the capital. While French is the official language, most islanders also speak Antillean Creole. As part of the European Union, the island uses the euro as its currency. When you arrive on an MSC Caribbean and Antilles cruise in Fort-de-France, you immediately notice the island’s steep hills, colourful colonial architecture, ornate balconies and tropical flowers. Book an MSC excursion to the Balata Cathedral, a miniature replica of the Sacré-Coeur in Montmartre, Paris, which offers a spectacular view of Fort-de-France and the bay. Before Martinique came to be known by its current name, it was once called Madinina,…
Day 24Pointe-a-Pitre, GuadeloupeNov 21, 2026 • Arrives at: 7 am • Departs at: 4 pm
When you arrive on an MSC Caribbean and Antilles cruise in Pointe-à-Pitre, Guadeloupe, you will discover a French gem in the Southern Caribbean, or as native islanders called it, “Karukera,” the “island of beautiful waters.” Guadeloupe’s Creole culture and cuisine are a melange of many influences, including French, African, Indian and East Asian. Take a scenic MSC excursion to the Guadeloupe National Park, designated a World Biosphere Reserve by UNESCO. Located in the south of Basse-Terre, the park has one of the most beautiful forests in the Caribbean and the highest peak on the island, the Soufrière volcano. Make your way to the three gorgeous waterfalls of Carbet on the lower slopes of La Soufrière. The second waterfall, about 360 feet in height, can be admired from a suspended bridge. Beautiful as they are, the waterfalls are among the most visited sites on Guadeloupe. The Valombreuse botanical garden is a must-see for those who love gardens, and with 500 species in its collection…
Day 25TortolaNov 22, 2026 • Arrives at: 7:30 am • Departs at: 3:30 pm
As you arrive on an MSC Caribbean and Antilles cruise in Tortola, the largest of the British Virgin Islands, it’s easy to see why pirates took refuge here among the hidden coves and sheltered bays, lush green mountains and powder-white sandy beaches. Today, its beauty continues to draw attention; Road Town, BVI’s capital, is a haven for yacht chartering, upscale tourism and offshore finance. You recognize Dutch and English colonial influences from a bygone era dominated by large sugarcane plantations built on the backs of enslaved African labour. Main Street, Road Town's main shopping district, features several historical landmarks including the Post Office, built in the mid-1800s, St. George's Anglican Church, Britannic Hall and the Virgin Islands' Folk Museum. Despite being a British protectorate, the U.S. dollar is used as Tortola’s main currency. The best way to discover Tortola is on an MSC excursion. Take a panoramic island bus tour through Road Town and the charming districts o…
Day 26Cruise returns to La RomanaNov 23, 2026 • Arrives at: 9 am
La Romana is a city on the Dominican Republic’s Caribbean coast and a gateway to nearby resort areas. Overlooking the Chavón River, Altos de Chavón is a re-created 16th-century Mediterranean village with artists' workshops. An obelisk painted with colorful images of local life stands in the city center. South of the city is Catalina Island, with beaches, coral reefs and the wrecked ship of pirate William Kidd.
Cabin options
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12 cabin grades listed for this sailing.
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