Rome (Civitavecchia) to Barcelona

Whether enjoying the street performers at the Spanish Steps and people-watching over a fine glass of wine in colorful Trastevere, or taking in the historical and architectural glory that is Rome, visitors are spoiled for choice in this truly Eternal City. St. Peter’s Basilica is a full-day outing, featuring the Sistine Chapel and panoramic city vistas for those willing to climb to the top of the dome. Other landmarks not to miss include the renowned Trevi Fountain, the Coliseum, and Aventine Hill, which provides you with a grand view of the imposing remains of the Imperial Palaces and the Circus Maximus, of Ben Hur fame.

Naples, a city in southern Italy, sits on the Bay of Naples. Nearby is Mount Vesuvius, the still-active volcano that destroyed nearby Roman town Pompeii. Dating to the 2nd millennium B.C., Naples has centuries of important art and architecture. The city's cathedral, the Duomo di San Gennaro, is filled with frescoes. Other major landmarks include the lavish Royal Palace and Castel Nuovo, a 13th-century castle.

Messina, the third largest city in Sicily, was the most important port of departure for European knights on their way to the Crusades in the Middle Ages. Today, this extensively rebuilt port city still boasts many historically and architecturally significant landmarks, particularly the renowned cathedral with its unusual astronomical clock, the 12th century Catania Church and the ornate Teatro Vittorio Emanuele. Messina is also the starting point for a day trip to the peak of breath-taking Mt. Etna-Crateri Silvestri.

Malta’s major port and capital, the entire city of Valletta was inscribed as a UNESCO World Heritage Site in 1980. The centerpiece is the impressive 19th century Mosta Dome, visible from anywhere on the island, with its inlaid marble floor and the gilded, carved stone flowers set around the interior dome. For a tranquil afternoon, stroll the San Anton Palace Gardens, artistically laid out in Three Villages - Attard, Lija and Balzan. Or, for spectacular vistas, take a day tour to Dingli Cliffs, which offer striking views of the sea and rugged coastline. Valetta is also a portal to day trips to nearby Mdina, with its landmark Baroque Cathedral of St. John; and Rabat, the provincial township that was once part of the Roman city of Melita, where you can explore several fascinating archaeological digs.

Travel across millennia as you visit the ruins of ancient Carthage and Tunis's opulent, historic medina with its winding alleys and souks. Visit the superb Bardo Museum with its spectacular Roman mosaics or the lovely whitewashed village of Sidi Bou Saïd perched on a cliff above the sea, a charming spot of cobbled streets, flower-filled courtyards and ornate window grills painted deep blue.

Savor this delightful old city spread over seven hills and its many attractions reflecting the influence of its numerous rulers. Climb to the citadel; visit the fabulous Archaeological Museum, Roman ruins and Pisan towers, early Byzantine churches, the Cathedral or the Botanic Gardens. Enjoy the nearby beach or discover the remains of Sardinia's ancient, enigmatic Nuraghe culture, their villages and huge burial caves.

Mallorca, also known as Majorca, is a wind-swept island with steep jagged cliffs and olive groves more than a thousand years old. Mallorca is an island of contrasts. To the south is a busy tourist area with hotels, bars, restaurants, shopping and dazzling night life. To the north are rocky valleys, sleepy villages shrouded in bougainvillea, and breathtaking views. Palma is dominated by the breathtaking Gothic Cathedral, located high above the waterfront on the site of a former mosque.

One of Europe’s most visually stunning cities, Barcelona balances the medieval intimacy of its Gothic Quarter with the grace and distinction of the wide boulevards in the Moderniste Eixample. It was the home of architect Antoni Gaudí, whose Sagrada Familia Cathedral, Park Güell and Casa Milà are the most profound statements of Modernisme. View the splendid works at the Picasso Museum and the Miro Foundation, or discover Barcelona’s passionate ambiance at a flamenco show.

Experience Costa Brava and understand why Salvador Dalí and others have long been inspired by its beaches and coves. Spend a day in the warm sand of La Fosca or learning about the history of this fishing village in Museu de la Pesca or simply taking in the Mediterranean air while walking down the promenade. Just an hour north of the city, you can visit the extraordinary Dalí Theatre-Museum in Figueres. The museum holds works done from his adolescence to the last years of his life.

Livorno is an Italian port city on the west coast of Tuscany. It's known for its seafood, Renaissance-era fortifications and modern harbor with a cruise ship port. Its central Terrazza Mascagni, a waterside promenade with checkerboard paving, is the city's main gathering place. The bastions of the 16th-century Fortezza Vecchia face the harbor and open onto Livorno's canal-laced Venezia Nuova quarter.

There is something for everyone in Alicante. The historic Mediterranean port city is located in renowned Costa Blanca, within the region of Valencia. From outdoor cafés to white-sand beaches to museums that house rare masterpieces, this town has everything one would expect of a Mediterranean escape. Be sure to visit the picturesque town of Guadalest, one of the most unique destinations in all of Spain.

Valencia was established by the Greeks and later occupied by the Carthaginians, Romans, Visigoths and Arabs. A 15th century artistic movement here gave the world spectacular paintings, sculptures, and jewels. Today a “City of Arts and Sciences,” Valencia offers visitors remarkable samples of modern architecture, alongside such notable classics as the 13th century Cathedral and Chapel of the Holy Chalice. Built on the site of a mosque which was originally a Roman temple the Chapel contains the chalice which legend says was used by Christ at the Last Supper. For a more historic view, take in the Quart Towers, a former gate of the medieval wall, built in 1444; and Serranos Towers, a former prison surrounded by a moat and built around 1391.

One of Europe’s most visually stunning cities, Barcelona balances the medieval intimacy of its Gothic Quarter with the grace and distinction of the wide boulevards in the Moderniste Eixample. It was the home of architect Antoni Gaudí, whose Sagrada Familia Cathedral, Park Güell and Casa Milà are the most profound statements of Modernisme. View the splendid works at the Picasso Museum and the Miro Foundation, or discover Barcelona’s passionate ambiance at a flamenco show.