Basel is a city on the Rhine River in northwest Switzerland, close to the country’s borders with France and Germany. Its medieval old town centers around Marktplatz, dominated by the 16th-century, red-sandstone Town Hall. Its 12th-century Gothic cathedral has city views, and contains the tomb of the 16th-century Dutch scholar, Erasmus. The city’s university houses some of Erasmus’ works.

Strasbourg is the capital city of the Grand Est region, formerly Alsace, in northeastern France. It's also the formal seat of the European Parliament and sits near the German border, with culture and architecture blending German and French influences. Its Gothic Cathédrale Notre-Dame features daily shows from its astronomical clock and sweeping views of the Rhine River from partway up its 142m spire.

Ludwigshafen am Rhein is a city in Rhineland-Palatinate, Germany, on the river Rhine, opposite Mannheim. With Mannheim, Heidelberg, and the surrounding region, it forms the Rhine Neckar Area. Known primarily as an industrial city, Ludwigshafen is the home of chemical giant BASF and other companies.

Rüdesheim am Rhein is a town in the Rhine Valley, Germany. It’s known for winemaking, especially of Riesling wines. In the center, Drosselgasse is a lane lined with shops, taverns and restaurants. Nearby, Siegfried’s Mechanical Music Cabinet is a museum of automated musical instruments. Medieval Brömserburg Castle is home to the Rheingau Wine Museum, exhibiting wine paraphernalia from ancient times to the present.

Frankfurt, a central German city on the river Main, is a major financial hub that's home to the European Central Bank. It's the birthplace of famed writer Johann Wolfgang von Goethe, whose former home is now the Goethe House Museum. Like much of the city, it was damaged during World War II and later rebuilt. The reconstructed Altstadt (Old Town) is the site of Römerberg, a square that hosts an annual Christmas market.

Miltenberg is a town in the Regierungsbezirk of Lower Franconia in Bavaria, Germany. It is the seat of the like-named district and has a population of over 9,000.

Wertheim is a town in southwestern Germany, in the state of Baden-Württemberg with a population of around 23,400. It is located on the confluence of the rivers Tauber and Main. Wertheim is best known for its landmark castle and medieval town centre.

Würzburg is a city in Germany's Bavaria region. It's known for lavish baroque and rococo architecture, particularly the 18th-century Residenz palace, with ornate rooms, a huge fresco by Venetian artist Tiepolo and an elaborate staircase. Home to numerous wine bars, cellars and wineries, Würzburg is the center of the Franconian wine country, with its distinctive bocksbeutel

Bamberg is a town in northern Bavaria, Germany, laid out over 7 hills where the Regnitz and Main rivers meet. Its old town preserves structures from the 11th to 19th centuries including the muraled Altes Rathaus (town hall), which occupies an island in the Regnitz reached by arched bridges. The Romanesque Bamberg Cathedral, begun in the 11th century, features 4 towers and numerous stone carvings.

Nuremberg is the largest city of the German federal state of Bavaria after its capital Munich, and its 518,370 inhabitants make it the 14th-largest city in Germany.