Istanbul rises from the Bosphorus, a vision of minarets and domes sparkling in the light. The capital of vanished empires, Istanbul is a true crossroad, the only city on Earth to span two continents. This meeting place of Europe and Asia, of Christian and Muslim, is one of the great adventures a traveler encounters. Browse the stalls of the world's largest bazaar, explore ancient mosques and churches, and gaze at the stunning jewels in the Topkapi Palace. Istanbul has dominated the Straits of Bosphorus for 25 centuries. As Constantinople, capital of the Eastern Roman Empire, it was a metropolis of stunning splendor when the great cities of Europe were mere villages.

Istanbul rises from the Bosphorus, a vision of minarets and domes sparkling in the light. The capital of vanished empires, Istanbul is a true crossroad, the only city on Earth to span two continents. This meeting place of Europe and Asia, of Christian and Muslim, is one of the great adventures a traveler encounters. Browse the stalls of the world's largest bazaar, explore ancient mosques and churches, and gaze at the stunning jewels in the Topkapi Palace. Istanbul has dominated the Straits of Bosphorus for 25 centuries. As Constantinople, capital of the Eastern Roman Empire, it was a metropolis of stunning splendor when the great cities of Europe were mere villages.

From the port of Kusadasi on Turkey's Anatolian Coast, one travels into the past. Nearby stand the ruins of ancient Ephesus, a major site of archeological excavation. The city was once a Roman provincial capital and trading center. Ephesus is also home to several of Christendom's holiest sites. St. Paul preached at the Great Theater and the ruins of Ephesus' Basilica cover the tomb of Christ's most beloved disciple, St. John the Apostle. In Kusadasi, whitewashed stone houses rise in tiers behind the market district. The palm-lined esplanade is the center of town life, with thousands of merchants offering wares to rival the Grand Bazaar in Istanbul.

The largest and arguably the most beautiful of the 12 islands forming the Dodecanese, Rhodes has long played a major role in history. Lying just 12 miles off the coast of Turkey, the island straddles the sea-lanes linking Egypt, Southern Europe and the Holy Land. Rhodes Town bears witness to that long history. The ancient city features a classical stadium and the ruins of the Temple of Apollo. The "old" city is a walled town with medieval buildings and streets harking back to the days of the Crusades. The new town is a Mecca of luxury resorts lining the island's picturesque Mandaraki Harbor. The Colossus of Rhodes, one of the Seven Wonders of the Ancient World, is reputed to have once stood guard over the harbor. Today, the bronze statues of a stag and doe top the two columns marking the harbor entrance.

Thanks to its proximity to the mainland, Mykonos was one of the first Greek islands to become an international travel destination. During the late '60s and early '70s, Mykonos was famed as a haunt for the rich. The island's nightlife - then and now - was a glittering whirl of colored lights, music, and parties. But there's another side to Mykonos - the neighboring island of Delos. In classical mythology, Delos was the birthplace of Apollo and his twin sister Artemis. Travelers to Delos can stroll among the island's vast ruins, which include three temples consecrated to the Sun God and the famed Lions Walk. Mykonos town features hip boutiques, restaurants, jewelry stores, souvenirs, taverns and cafés. The island's famed windmills are found just south of the waterfront.

Archaeological evidence shows that Heraklion probably arose during the 9th century B.C. and was named in tribute to the Greek goddess Rhea, mother of Zeus. And like most Mediterranean cities, Heraklion has a long and turbulent history. Officially founded by the Saracens in the 9th century, the Byzantine Empire invaded in 961 only to lose control to the Crusaders who sold Crete to the Venetians in 1211 for a thousand silver coins. Heraklion finally flourished under the Venetians. Throughout the city you'll find stunning reminders of their influence: the Loggia, Venetian Walls, and Fountain of Morosini are just a few must-see examples. But Heraklion is probably best known as the gateway to the breathtaking 4,000 year-old Minoan ruins at Knossos and to the famous windmills stretched across the Lassithi Plateau.

Messina has played a major role in European history since its founding as a Greek colony in the 8th century B.C. During the Roman Empire, the city was a major port and commercial center, during the Middle Ages, Messina was the major port of departure for Crusaders. History has also left its scars: a massive earthquake leveled much of the city in 1908 and the World War II campaign for Sicily devastated Messina. Yet Messina emerged from that devastation with some of its historic treasures intact, including the 12th-century Annunziata dei Catalani Church. Messina is also your gateway to the rugged beauty of southeast Sicily, from the seaside resort of Taormina to Mt. Etna. Between the fall of Rome and the 1861 unification of Italy, the Arabs, the Normans, the Germans, the Spanish and the French ruled Sicily.

Malta is the largest in a group of seven islands that occupy a strategic position between Europe and Africa. The island's history is long and turbulent. Everyone from the Normans to the Nazis have vied for control of this small, honey-colored rock. For centuries the island was the possession of the knightly Order of St. John - the Knights Hospitaller. Valletta, Malta's current capital, was planned by the Order's Grandmaster Jean de la Valette to secure the island's eastern coast from Turk incursions. Founded in 1566, Valletta's bustling streets are lined with superb Baroque buildings and churches. Malta has a long history: the megalithic stone temples at Gozo may be the oldest freestanding structures on Earth. Malta has two official languages, Maltese (constitutionally the national language) and English. Malta was admitted to the European Union in 2004 and in 2008 became part of the eurozone.

Palermo is a cultural feast, a fascinating combination of East and West, Arab and Norman that is quite unlike any other European city on the Mediterranean. A simple stroll can serve to illustrate Palermo's rich heritage. The Quattro Canti is the great square at the heart of the city. A short walk past its 17th-century palazzos and fountains brings the traveler to the Palazzo dei Normanni. Begun by Arab emirs in the 9th century, the Palazzo was finished by the island's Norman conquerors. The Palazzo's stone arches and buttresses stand in stark contrast to its Palatine Chapel. There elaborate tile work and mosaics lend mute testimonies to the Islamic and Byzantine influences that a lso shaped Palermo's culture. The city abounds in such colorful sights, from the neo-classical Teatro Massimo, one of the largest opera houses in Europe, to the catacombs beneath the Capuchin convent, where thousands of mummified bodies lie in eternal rest.

Italy's third-largest city, Naples is a bustling metropolis famed for it stately buildings, crowded streets, pizza - and notoriously bad traffic. However, this beautiful city is rich in centuries-old culture and customs. Naples is also your gateway to the Isle of Capri, the fabled Amalfi Coast and the ruins of Pompeii, buried in ash by the cataclysmic eruption of Mt. Vesuvius in 79 A.D. Naples boasts an ideal location, with both the ruins of Roman cities and the stunning Amalfi Coast in easy reach.

Your gateway to the Eternal City, Civitavecchia has served as Rome's seaport since the 13th century. The port has a long and venerable history. The emperor Trajan built a pleasure villa near the modern city, while Bernini and Michelangelo designed the harbor fortifications. Yet the Eternal City eternally beckons. The ancient capital of the Western World and the center of Christianity for nearly 2,000 years, Rome provides an inexhaustible feast. Visit the ruins of the Forum, view the splendors of the Sistine Chapel, or climb the Spanish Steps, once the heart of Rome's Bohemian Quarter. Rome has been a magnet luring the world's greatest artists, architects, and philosophers since the days of the Caesars.