Venice, the capital of northern Italy’s Veneto region, is built on more than 100 small islands in a lagoon in the Adriatic Sea. It has no roads, just canals – including the Grand Canal thoroughfare – lined with Renaissance and Gothic palaces. The central square, Piazza San Marco, contains St. Mark’s Basilica, which is tiled with Byzantine mosaics, and the Campanile bell tower offering views of the city’s red roofs.

Zadar, a city on Croatia’s Dalmatian coast, is known for the Roman and Venetian ruins of its peninsular Old Town. There are several Venetian gates in the city walls. Surrounding the Roman-era Forum is 11th-century St. Mary’s Convent, with religious art dating to the 8th century. There’s also the grand, 12th-century St. Anastasia’s Cathedral and the round, 9th-century pre-Romanesque Church of St. Donatus.

Hvar is a port and resort town on the Croatian island of Hvar. Yachts fill its harbor in summer. Ferries connect the town with the several Pakleni Islands just offshore. These are home to secluded beaches, such as those around Ždrilca Bay, as well as rocky coves and pine forests. Hula Hula Beach in Hvar and Stipanska Beach on Marinkovac Island are known for their nightlife and lively bars.

Dubrovnik is a city in southern Croatia fronting the Adriatic Sea. It's known for its distinctive Old Town, encircled with massive stone walls completed in the 16th century. Its well-preserved buildings range from baroque St. Blaise Church to Renaissance Sponza Palace and Gothic Rector’s Palace, now a history museum. Paved with limestone, the pedestrianized Stradun (or Placa) is lined with shops and restaurants.

Otranto is a coastal town in southern Italy’s Apulia region. It’s home to the 15th-century Aragonese Castle and 11th-century Otranto Cathedral, with a rose window and ornate mosaic flooring. At the harbor, Torre Matta tower has sweeping sea views. Nearby beaches include the popular Alimini Beach. Inland are 2 lakes: the saltwater Alimini Grande and spring-fed Alimini Piccolo. South is the Punta Palascìa lighthouse.

Giardini Naxos is a comune in the Metropolitan City of Messina on the island of Sicily in southern Italy. It is situated on the coast of the Ionian Sea on a bay which lies between Cape Taormina and Cape Schisò. Since the 1970s it has become a seaside-resort.

Valletta (or Il-Belt) is the tiny capital of the Mediterranean island nation of Malta. The walled city was established in the 1500s on a peninsula by the Knights of St. John, a Roman Catholic order. It’s known for museums, palaces and grand churches. Baroque landmarks include St. John’s Co-Cathedral, whose opulent interior is home to the Caravaggio masterpiece "The Beheading of Saint John."

Porto Empedocle is a town and comune in Italy on the coast of the Strait of Sicily, administratively part of the province of Agrigento. It is the namesake of Empedocles, a Greek pre-Socratic philosopher and a citizen of the city of Akragas, in his day a Greek colony in Sicily.

Trapani is a city in western Sicily with a crescent-shaped coastline. At the western tip, offering views as far as the Aegadian Islands, is the 17th-century Torre di Ligny watchtower. It houses the Museo di Preistoria e del Mare, with archeological artifacts. North of the harbor, the Chiesa del Purgatorio church holds wooden sculptures that are paraded around the city during Easter’s Processione dei Misteri.

Amalfi is a town in a dramatic natural setting below steep cliffs on Italy’s southwest coast. Between the 9th and 11th centuries, it was the seat of a powerful maritime republic. The Arab-Norman Sant'Andrea cathedral at the heart of town, with its striped Byzantine facade, survives from this era. The Museo Arsenale Amalfi is a medieval shipyard-turned-exhibition space.

Civitavecchia is a coastal town northwest of Rome, in Italy. Built in the 2nd century, the Port of Civitavecchia still retains some of its original features, like the Roman Dock. The port area also includes the 16th-century Michelangelo Fort. Nearby, the National Archaeological Museum displays bronze and ceramic artifacts. Northeast of town are the Terme Taurine, the ruins of a Roman thermal bath complex.