Rome (Civitavecchia), Italy to Lisbon, Portugal

Travel to Rome and revel in the magnificent monuments, from the ancient Roman Forum and Coliseum to the splendor of St. Peter's Basilica with Michelangelo's Pietà and his breathtaking frescoes in the Sistine Chapel. Or enjoy a drive through the lush farmlands of the Roman countryside to lovely medieval Castelgandolfo.

Spend a glorious day amidst the fabled architecture of this Renaissance city. See the Duomo with Brunelleschi's dome, the famous baptistry, Michelangelo's magnificent David, the bridge over the Arno and the astonishing Uffizi Gallery. Visit Pisa's superb Campo dei Miracoli and its beautiful cathedral and famed campanile. Or enjoy the Tuscan countryside, Siena and San Gimignano, renowned for its medieval towers. Shopping: Find leather goods, lingerie, gold jewelry, Florentine mosaic, lace, marbled paper items, antiques and fine art. Dining: Savor the prosciutto, pecorino cheese and infinite variety of breads, cakes and salamis.

Embraced by Nice and the picturesque village of Saint-Jean-Cap-Ferrat, the bay of Villefranche is considered one of the most beautiful in the world. In the heart of the Côte d’Azur, Villefranche invites you to uncover its old-fashioned charms among the lanes of its 14th-century old town and seaside cafés. Nice also enchants with its superb medieval ambiance, particularly at the Cours Saleya markets in the old quarter, where the scents of the bustling flower stalls waft through the streets. The hilltop village of Eze, another nearby French Riviera gem, offers mesmerizing views from its location on a rocky peak above the Mediterranean.

Located on the eastern shores of Spain’s Costa Brava, Palamos is a small and walkable city with beautiful beaches and a lovely promenade lined with restaurants and cafés. Learn about the history and the art of fishing at the popular Fishing Museum. Travel outside the city to visit the renowned Dali Museum, where the museum itself is as much of an attraction as the works of Salvador Dali that adorn its walls.

Visit the magnificent Gothic cathedral and the amazing La Sagrada Familia, Antoni Gaudí's unfinished masterpiece. Enjoy the lovely Montjuic Gardens, Gaudí's other fabulous structures, the charming squares of the old Gothic Quarter and the Ramblas, Barcelona's famed downtown promenade. Or visit beautiful Montserrat and its monastery in a breathtaking setting high in the mountains.

Explore this beautiful island beginning with the magnificent Seo Cathedral and Bellver Castle. See the windmills and impressive manor house in the verdant countryside. Discover the amazing natural wonders in the Drach Caves. And for romance, visit the former Carthusian monastery in Valldemosa, where George Sand and Chopin spent a winter.

Spend a day in Granada seeing the magnificent Alhambra and Generalife Gardens, last stronghold of the Moors, or venture into the mountains to the picturesque Mijas, one of Andalusia's dazzling "white" towns. Explore delightful Málaga, its Alcazaba, Roman theater and beautiful cathedral, or discover the charming resorts of Marbella and Puerto Banus along the famed Costa del Sol.

Go to the top of the Rock and admire the view across the Mediterranean and up the peninsula into Spain. Feed peanuts to the famed Barbary Apes and visit St. Michael's Cave, a fascinating cavern once lived in by Neolithic peoples and visited by early Romans. See the quaint fishing village along the coast and enjoy the colorful town. Shopping: Browse through shops filled with lovely embroidered linens from Madeira. Dining: Enjoy some traditional fish and chips with a beer or just relax in a café and watch the passing parade.

Situated on the sun-kissed coastline of Algarve, Portimão is a colorful city with a bustling waterfront and a charming city center decorated with parks and plazas. The Museum of Portimão traces the history of human settlement in the area as far back as the Roman and Islamic periods. Enjoy beautiful views and explore hidden caves on a scenic boat trip up the coast and along the Rio Arade.

Visit the ornate Belem Tower and Jeronimos Monastery and stroll the narrow, winding streets of the charming Alfama district. Enjoy marvelous old Sintra, a royal country retreat, and Cascais, a beautiful seaside resort. Explore medieval Obidos or make a pilgrimage to Fatima, where the Virgin Mary appeared repeatedly to three shepherd children in 1917.